Dihydropyridines and verapamil inhibit voltage-dependent K+ current in isolated outer hair cells of the guinea pig
References (45)
- et al.
Bound and determined: a computer program for making buffers of defined ion concentrations
Anal. Biochem.
(1992) - et al.
Voltage-dependent ion channels in T-lymphocytes
J. Neuroimmunol.
(1985) - et al.
Verapamil interaction with the muscarinic receptor: stereoselectivity at two sites
Biochem. Pharmacol.
(1987) - et al.
The effects of quinine on the cochlear mechanics in the isolated temporal bone preparation
Hearing Res.
(1991) - et al.
A characterization of the activating structural rearrangements in voltage-dependent shaker K+ channels
Neuron
(1994) - et al.
Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons
Neurosci. Lett.
(1989) - et al.
Ionization and surface properties of verapamil and several verapamil analogues
J. Pharm. Sci.
(1986) - et al.
Active radial and transverse motile responses of outer hair cells in the organ of Corti
Hear Res.
(1990) - et al.
Whole cell currents and mechanical responses of isolated outer hair cells
Hearing Res.
(1988) - et al.
Comparison of isolated outer hair cells from five mammalian species
Hearing Res.
(1987)
Characteristics of the inhibition of ligand binding to serotonin receptors in rat brain membranes by verapamil
Jpn J. Pharmacol.
Ionic currents in molluscan soma
A. Rev. Neurosci.
Non-selective conductance in calcium channels of frog muscle: calcium selectivity in a single-file pore
J. Physiol. (Lond.)
Inactivation of the potassium conductance and related phenomena caused by quaternary ammonium ion injection in squid axons
J. Gen. Physiol.
Charge movement associated with the opening and closing of the activation gates of the Na channels
J. Gen. Physiol.
Control of intracellular calcium by ATP in isolated outer hair cells of the guinea-pig cochlea
J. Physiol.
Nimodipine and L-channel Ca2+ antagonist, reverses the negative summating potential recorded from the guinea pig cochlea
Hearing Res.
Evoked mechanical responses of isolated cochlear outer hair cells
Science
The active cochlea
J. Neurosci.
Specificity of tetraethylammonium and quinine for three K channels in insulin-secreting cells
J. Membr. Biol.
The interaction of verapamil and norverapamil with beta-adrenergic receptors
Circulation
Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones
J. Physiol. (London)
Cited by (36)
Ion flow in cochlear hair cells and the regulation of hearing sensitivity
2011, Hearing ResearchCitation Excerpt :There is also some debate about the density of L-type channels in OHCs. Unfortunately some blockers of these channels used to identify them experimentally have been shown to also block K+ conductances, confusing interpretation of experiments (Xi Lin et al., 1995). It is also not clear if they are functional in normal OHCs at rest.
BAY-K 8644
2009, xPharm: The Comprehensive Pharmacology ReferenceThe coupling of acetylcholine-induced BK channel and calcium channel in guinea pig saccular type II vestibular hair cells
2007, Brain ResearchCitation Excerpt :ACh-induced BK current in VHCs II of guinea pig end-organs was inhibited by nifedipine (Kong et al., 2005). Nifedipine is known to be a calcium channel blocker as well as a potassium channel blocker, which could directly inhibit voltage-dependent K+ current in OHCs (Lin et al., 1995). Although it is hard to make a conclusion that the principal role of nifedipine was to inhibit the opening of L-type calcium channels, the present data demonstrated that the direct physiological evidences that calcium channels and BK channels were co-localized in guinea pig saccular VHCs II and the opening of the calcium channels is the source of the calcium influx.
The properties of ACh-induced BK currents in guinea pig type II vestibular hair cells
2005, Hearing ResearchLead (Pb<sup>2+</sup>) modulation of potassium currents of guinea pig outer hair cells
2004, Neurotoxicology and Teratology
- 1
Present address: Auditory Physiology Laboratory (The Hugh Knowles Center) and Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA.