Biodegradation characteristics of acyclovir 2′-esters by respiratory carboxylesterases: Implications in prodrug design for intranasal and pulmonary drug delivery
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2021, Journal of Pharmaceutical SciencesCitation Excerpt :β-cyclodextrin complexes with acyclovir also increased significantly the drug solubility in water (7.6-fold), pH 1.2 (9.5-fold), and pH 7.4 (6-fold), which is an interesting finding when a high-dose of acyclovir is needed to treat infections. Administration of acyclovir prodrugs represents an approach to improve drug absorption and bioavailability.97–101 Besides improving the permeability parameters, prodrugs can have a high affinity for influx transporters, increasing the drug absorption rate.
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