Journal of Chromatography B: Biomedical Sciences and Applications
Regular paperHigh-performance liquid chromatographic assay for the measurement of melphalan and its hydrolysis products in perfusate and plasma and melphalan in tissues from human and rat isolated limb perfusions
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A rapid and sensitive LC-MS/MS method for simultaneous determination of melphalan and its monohydroxy and dihydroxy metabolites in human plasma
2023, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesAnalysis of anticancer drugs: A review
2011, TalantaCitation Excerpt :Guetens et al. published a review of hyphenated techniques for anticancer drug monitoring, including GC–MS and LC–MS methods, for melphalan in 2002 [23,24]. LC-UV [300–302], LC-ECD [303] and LC with fluorescence detection [304–306] were also used for the determination of melphalan in biological samples. More recently, LC–MS/MS methods were developed for TDM and pharmacokinetic studies on melphalan [307,308].
Assays for the quantification of melphalan and its hydrolysis products in human plasma by liquid chromatography-tandem mass spectrometry
2009, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesA Multi-Institutional Experience of Isolated Limb Infusion: Defining Response and Toxicity in the US
2009, Journal of the American College of SurgeonsCitation Excerpt :Additionally, in terms of optimal drug delivery, patients who had a response to treatment (PR + CR) had significantly smaller limb volume (6.45 L ± 2.1L) than those who did not respond (8.01 L ± 3.47 L) (p = 0.021). This observation suggests that drug distribution can be important in determining response and, as supported by SMU microdialysis studies, that drug distribution is better achieved in smaller limbs as opposed to larger limbs.24 An additional modification to ILI performed at some centers is correction of the melphalan and dactinomycin doses for IBW.
Liposomes loaded with lipophilic prodrugs of methotrexate and melphalan as convenient drug delivery vehicles
2009, Journal of Drug Delivery Science and TechnologyCharacterization of a membrane-associated apoplastic lipoxygenase in Phaseolus vulgaris L.
2005, Biochimica et Biophysica Acta - Proteins and Proteomics