Cloning, sequence analysis and expression of the gene encoding the mouse bradykinin B2 receptor
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Kinin B2 receptor can play a neuroprotective role in Alzheimer's disease
2015, NeuropeptidesCitation Excerpt :In the rat hippocampus, a single dose of BK promotes hyperphosphorylation of the Tau protein eliciting memory and learning impairment (Wang and Wang, 2002). Kinin B2R is widely distributed in the CNS, being described in several nuclei of rats (Cholewinski et al., 1991; Couture and Lindsey, 2000; Viel et al., 2008), mice (Ma et al., 1994a), guinea pigs (Lopes et al., 1983; Sharif and Whiting, 1991; Murone et al., 1997; Fujiwara et al., 1988), bovine cattle (Kozlowski et al., 1998) and humans (Ma et al., 1994b; Raidoo et al., 1996) as assessed by RT-PCR, immunohistochemistry and autoradiography. Alzheimer's disease (AD) is a progressive neurodegenerative disease with severe impact on learning and memory.
Control of ENaC-mediated sodium reabsorption in the distal nephron by Bradykinin
2015, Vitamins and HormonesCitation Excerpt :The physiological actions of the KKS are mainly mediated by BK and have both beneficial (vasodilation, natriuresis, diuresis, decrease in insulin resistance, etc.) and detrimental (pain, inflammation, allergy, and edema) consequences (Regoli et al., 2012). B2R are constitutively expressed in many tissues, such as smooth muscles, neurons, vascular endothelium, and kidney epithelial cells (Ma, Wang, Chao, & Chao, 1994). In contrast, expression of B1R is low during normal physiology but is markedly upregulated by tissue injury and inflammation (Marceau, Larrivee, Saint-Jacques, & Bachvarov, 1997).
The Influence of Gender on Cough Reflex Sensitivity
2004, Principles of Gender-Specific MedicineKinin receptors in cultured rat microglia
2004, Neurochemistry InternationalStructure of the mammalian kinin receptor gene locus
2002, International ImmunopharmacologyUpregulation of bradykinin B2 receptor expression by neurotrophic factors and nerve injury in mouse sensory neurons
2002, Molecular and Cellular Neuroscience