Effects of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkeys
References (21)
- et al.
Interaction of [3H]GBR 12935 and GBR 12909 with the dopamine uptake complex in nucleus accumbens
Eur. J. Pharmacol.
(1990) - et al.
Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: Specific inhibitors of dopamine uptake
Eur. J. Pharmacol.
(1984) - et al.
Tight binding dopamine reuptake inhibitors as cocaine antagonists
Fed. Eur. Biochem. Soc. Lett.
(1989) - et al.
Amantadine: evaluation of reinforcing properties and effect on cocaine self-administration in baboons
Drug Alcohol Depend.
(1988) - et al.
Drug-reinforced responding: rapid determination of dose-response functions
Drug Alcohol Depend.
(1989) - et al.
Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys
J. Pharmacol. Exp. Ther.
(1989) - et al.
Narcotic blockade
Arch. Int. Med.
(1966) Chronic neuropharmacology of cocaine: progress in pharmacotherapy
J. Clin. Psychiatry
(1988)- et al.
Characterization of the effects of cocaine and GBR 12909, a dopamine uptake inhibitor, on behavior in the squirrel monkey
J. Pharmacol. Exp. Ther.
(1991) - et al.
The pharmacology of cocaine related to its abuse
Pharmacol. Rev.
(1989)
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Effects of GPR139 agonism on effort expenditure for food reward in rodent models: Evidence for pro-motivational actions
2022, NeuropharmacologyCitation Excerpt :Among these, the feeding regimen and therefore degree of satiety at the onset of testing would be expected to be particularly important. It is well known that satiety manipulations markedly influence the vigor of responding in operant tasks for gustatory reward, e.g. pre-test feeding reduces food motivation and breakpoints (Hailwood et al., 2018; Salamone et al., 1991; Skjoldager, 1993). Notably, our rats were maintained under a moderately restrictive feeding regimen, which enhanced motivation for food and the effort expended to receive sucrose reward.
Noradrenergic circuits and signaling in substance use disorders
2022, NeuropharmacologyCitation Excerpt :Lesion of the VNB also had no effect on the maintenance phase of cocaine self-administration (Roberts et al., 1977). Further, selective NET inhibitors are generally not self-administered, while DAT inhibitors are self-administered (Skjoldager et al., 1993; Wee et al., 2006; Woolverton, 1987). Together, these data suggest that NE is not involved in the maintenance of psychostimulant self-administration.
Cocaine, hormones, and behavior: Clinical and preclinical studies
2009, Hormones, Brain and Behavior OnlineDopamine transport inhibitors based on GBR12909 and benztropine as potential medications to treat cocaine addiction
2008, Biochemical PharmacologyCitation Excerpt :Such data demonstrate that factors in addition to DAT binding affinity must be involved in mediating the in vivo reinforcing actions of these drugs. GBR12909 has been found to serve as a reinforcer in several species [39–42]. Studies showed that GBR12909 can maintain rates of drug-appropriate responding in animals trained to self-administer cocaine, as well as substitute for cocaine [43–49].
Prefrontal cortex D1 modulation of the reinforcing properties of cocaine
2006, Brain ResearchCitation Excerpt :Similarly, hyperlocomotion stimulated by intra-NAcc D1 agonist (SKF 38393) is enhanced 48 h following intra-PFC SCH 23390, although intra-NAcc amphetamine-stimulated hyperlocomotion is diminished 48 h post-infusion (Vezina et al., 1994). Systemic pretreatments with amphetamine (Lynch et al., 1998; Negus and Mello, 2003), GBR 12909 (Skjoldager et al., 1993; Tella, 1995), phentermine (Wojnicki et al., 1999) and a D1 agonist (Platt et al., 2001) all elevate NAcc levels and lead to decreased cocaine self-administration. Previously, we observed elevations in NAcc DA 24 h after intra-PFC infusions of a low dose of the D1 antagonist, SCH23390 (Olsen and Duvauchelle, 2001).