Changes in benzodiazepine-receptor activity modify morphine withdrawal syndrome in mice
References (47)
- et al.
Does Ro. 15-4513 reverse the anxiolytic effects of ethanol by its intrinsic properties?
Pharmacol. Biochem. Behav.
(1988) - et al.
Enigmatic action of cyclosporine A on the naloxone-precipitated morphine withdrawal syndrome in mice
Neuroscience
(1989) - et al.
Effects of ethylenediamine on morphine analgesia and tolerance dependence in mice
Gen. Pharmacol.
(1985) - et al.
Effects of GABA transaminase upon some morphine effects
Neuropharmacology
(1979) - et al.
Comparative study in mice of flunitrazepam vs. diazepam on morphine withdrawal syndrome
Prog. Neuro-Psychopharmacol. Biol. Psychiat.
(1988) Benzodiazepine interactions with GABA receptor
Neurosci. Lett.
(1984)- et al.
Photoaffinity labelling of benzodiazepine-receptors with a partial inverse agonist
Eur. J. Pharmacol.
(1984) - et al.
Separation of clonazepam-induced head twitches and muscle relaxation in mice
Pharmacol. Biochem. Behav.
(1983) - et al.
Studies on the involvement of opioid mechanism in the locomotor effects of benzodiazepine in rats
Pharmacol. Biochem. Behav.
(1991) Benzodiazepine-induced shaking behaviour in the rat: structure, activity and relation to serotonin and benzodiazepine receptors
Exp. Neurol.
(1989)
GABAergic regulation of striatal opioid gene expression
Brain Res. (Mol. Brain Res.)
Benzodiazepine-induced antagonism of opioid antinociception may be abolished by spinalization or blockade of the benzodiazepine receptor
Pharmacol. Biochem. Behav.
Reduction in the number of serotonin receptors in the brainstem of morphine dependent rats: relation to blockade of naloxone precipitated jumping by serotonin agonists
Life Sci.
Gabaergic drugs, morphine and morphine tolerance. A study in relation to nociception and gastrointestinal transit in mice
Neuropharmacology
Effects of clonidine on morphine withdrawal signs in the rat
Eur. J. Pharmacol.
Diazepam-induced release of opioid activity in the rat brain
Neurosci. Lett.
Cortical acetylcholine release is increased and gamma-aminobutyric acid outflow is reduced during morphine withdrawal
Br. J. Pharmacol.
Dopaminergic mechanisms in precipitated withdrawal in morphine dependent rats
J. Pharmacol. Exp. Ther.
Similar effects of a beta-carboline and of flumazenil in negatively and positively reinforced learning tasks in mice
Life Sci.
Effects of antispychotic and antianxiety drugs on morphine abstinence syndrome in rats
J. Pharmacol. Exp. Ther.
Behavioural effects of the benzodiazepine receptor partial agonist Ro. 16-6028 in mice
Psychopharmacology
Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats
Psychopharmacologia
An azido analogue of the benzodiazepine antagonist Ro. 15-1788 (Ro. 15-4513) behaves as partial inverse agonist
Neurosci. Lett. Suppl.
Cited by (16)
GABA withdrawal syndrome: GABA<inf>A</inf> receptor, synapse, neurobiological implications and analogies with other abstinences
2016, NeuroscienceCitation Excerpt :When GABA-produced hyperexcitability is present, neurons of the somatomotor cortex that exhibit an increase in their activity also demonstrate a decrease in the activity of the muscarinic receptors (Silva-Barrat et al., 2001), an increase in the activation of narcotic receptors (Silva-Barrat et al., 2005), and a decrease in the outward current of K+, (Silva-Barrat and Champagnat, 1995), as well as an increase in the expression of the acetyl-cholinesterase enzyme in epileptic discharge foci (Araneda et al., 1994). Withdrawal induced by the interruption of the administration of drugs such as benzodiazepines produces an increase in the expression of opioid receptors and, in addition, pre-treatment with benzodiazepines decreases the symptoms of morphine abstinence (MA) (Valverde et al., 1992; Suzuki et al., 1996). These synaptic changes suggest a functional and neurochemical arrangement in the brain cortex and hippocampus as a consequence of the hyperexcitability produced by the abstinences.
The effects of diazepam dependence and withdrawal on morphine-induced antinociception and changes in locomotion in male and female rats
2001, Pharmacology Biochemistry and BehaviorStudy of the mechanisms involved in behavioral changes induced by flunitrazepam in morphine withdrawal
1995, Progress in Neuropsychopharmacology and Biological PsychiatryIntracisternal administration of interleukin-1β attenuates naloxone-precipitated withdrawal in morphine-dependent mice
1995, European Journal of Pharmacology
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Present address: Unité de Pharmacochimie Moléculaire. INSERM U 266. Faculté de Pharmacie. 4, avenue de l'Observatoire. 75006 Paris, France.