Origin and termination of the diencephalo-spinal dopamine system in the rat
References (23)
- et al.
The aluminum-formaldehyde (ALFA) histofluorescence method for improved visualization of catecholamines and indoleamines. 2. Model experiments
J. Neurosci. Meth.
(1980) - et al.
Evidence for a major spinal cord projection from the diencephalic A11 dopamine cell group in the rat using transmitter-specific fluorescent retrograde tracing
Brain Res.
(1979) - et al.
Simultaneous use of retrograde fluorescent tracers and fluorescence histochemistry for convenient and precise mapping of monoaminergic projections and collateral arrangements in the CNS
J. Neurosci. Meth.
(1979) - et al.
Direct projection of catecholamine (presumably dopamine) containing neurons from hypothalamus to spinal cord
Neurosci. Lett.
(1979) - et al.
Current status of dopamine in the mammalian spinal cord
Biochem. Pharmac.
(1979) - et al.
Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range
Life Sci.
(1976) - et al.
Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain
Brain Res.
(1974) - et al.
The aluminum-formaldehyde (ALFA) histofluorescence method for improved visualization of catecholamines and indoleamines. 1. A detailed account of the methodology for central nervous tissue using paraffin, cryostat or vibratome sections
J. Neurosci. Meth.
(1980) - et al.
Direct hypothalamoautonomic connections
Brain Res.
(1976) - et al.
Assessment of the effects of neonatal subcutaneous 6-hydroxydopamine on noradrenergic and dopaminergic innervation of the cerebral cortex
Brain Res.
(1979)
Cited by (209)
Spinal dopaminergic D<inf>1</inf> and D<inf>5</inf> receptors contribute to reserpine-induced fibromyalgia-like pain in rats
2023, Brain ResearchCitation Excerpt :Dopamine is an important neurotransmitter modulating a broad range of behaviors including reward, affect, attention, voluntary movement, and cognitive process, among others (Beaulieu et al., 2015). Spinal dopamine is released from descending dopaminergic projections arising from the hypothalamic A11 nucleus (Skagerberg et al., 1982; Skagerberg and Lindvall, 1985; Koblinger et al., 2014). There is evidence that pharmacological activation of D2-like dopamine receptors in A11 nucleus or electrical stimulation of these neurons increase withdrawal thresholds in naïve and neuropathic conditions, respectively (Wei et al., 2009; Taniguchi et al., 2011).
Differential dopamine modulation of spinal reflex amplitudes is associated with the presence or absence of the autonomic nervous system
2021, Neuroscience LettersCitation Excerpt :Dopaminergic inputs to the spinal cord stem from the A11 cell group in the dorso-0-posterior hypothalamus [6–8,47]. These DA fibers project extensively through the entire spinal gray, including the motoneuron (MN) pools in the ventral horn and the intermediolateral nucleus (IML), the final common output of the autonomic nervous system [6,7,9,10,47]. DA acts through two different receptor subfamilies, D1-like (D1, D5) and D2-like (D2, D3, D4) that generally mediate opposing excitatory (D1-like) or inhibitory (D2-like) actions.
D2-like receptor agonist synergizes the μ-opioid agonist spinal antinociception in nociceptive, inflammatory and neuropathic models of pain in the rat
2019, European Journal of PharmacologyD3 and D1 receptors: The Yin and Yang in the treatment of restless legs syndrome with dopaminergics
2019, Advances in PharmacologyMechanistic evaluation of tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats
2017, European Journal of PharmacologyCitation Excerpt :The role of dopamine in pain processing and suppression is well known, and activation of opioid receptors in midbrain areas like hypothalamus leads to dopamine increase in spinal cord (Pappas et al., 2011). Dopaminergic neurons in spinal cord are mainly present in the dorsal horn, lamina X and in the ventral horn (Skagerberg et al., 1982; Yoshida and Tanaka, 1988; Ridet et al., 1992), which are innervated mainly from the A11 cell group and to some extent from the paraventricular nucleus of hypothalamus (Skagerberg et al., 1982; Skagerberg and Lindvall, 1985; Wei et al., 2009). This hypothesis is corroborated by the report that systemic administration of µ-opioid receptor agonist, morphine increased spinal dopamine levels and this effect was antagonized by pretreatment with opioid antagonist, naloxone (Pappas et al., 2011).
- 1
Present address: Department of Pharmacology, Basic Sciences Building, The University of Iowa, Iowa City, Iowa 522242.