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2010, Schizophrenia ResearchCitation Excerpt :Our study has demonstrated that the in vivo GABA concentrations of the ACC and the ltBG did not differ significantly between medicated chronic schizophrenia patients and healthy control subjects. Animal studies have reported that typical antipsychotics increased the expression of GAD67 and GAD67 mRNA in the basal ganglia (Chen and Weiss, 1993; Johnson et al., 1994; Jolkkonen et al., 1994; Delfs et al., 1995a,b; Laprade and Soghomonian, 1995; Sakai et al., 2001), but that administration of atypical antipsychotic drugs did not (Delfs et al., 1995a; Sakai et al., 2001). Our observation of significantly higher GABA concentrations in the TYP group compared to the ATY group is therefore compatible with the findings of these animal studies.
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