Capsaicin-induced activation of fine afferent fibres from rat skin in vitro
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Role of TRPV1 receptors on panic-like behaviors mediated by the dorsolateral periaqueductal gray in rats
2013, Pharmacology Biochemistry and BehaviorCitation Excerpt :Accordingly, previous work from our group showed that intra-dlPAG administration of TRPV1 antagonists also caused a panicolytic-like effect in escape reactions induced by electrical stimulation of dlPAG (Casarotto et al., 2012). Capsazepine acts as a competitive antagonist in a variety of bioassays, blocking the effects of capsaicin, a potent agonist of these receptors (Belvisi et al., 1992; Dickenson and Dray, 1991; Seno and Dray, 1993). Nonetheless, we cannot exclude the involvement of other targets in capsazepine effects, since it may also block different channels of the TRP family, including TRPM8 (Malkia et al., 2009; Xing et al., 2007).
Effect of capsaicin treatment on nociceptors in rat glabrous skin one day after plantar incision
2010, PainCitation Excerpt :Most capsaicin-sensitive nociceptors are C-fibers, and especially when low concentrations are utilized, capsaicin is highly selective for activating or desensitizing C-fibers [14,18,31]. Previous studies have demonstrated, in vivo and in vitro, that over 90% of mechano-heat-sensitive C-fibers in rat skin are capsaicin-sensitive [18,28]. In our previous study using the rat in vitro glabrous skin–tibial nerve preparation, about 80% of C-mechanonociceptors from unincised skin were heat-sensitive [4].
Effects of capsaicin on Ca<sup>2+</sup> release from the intracellular Ca<sup>2+</sup> stores in the dorsal root ganglion cells of adult rats
2001, Biochemical and Biophysical Research CommunicationsNociceptor excitation by thermal sensitization - A hypothesis
2000, Progress in Brain Research