Cloning of human neurotensin/neuromedin n genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls
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Cited by (54)
Gastrointestinal Hormones
2018, Physiology of the Gastrointestinal Tract, Sixth EditionChanges in expression levels of neurotensin precursor and receptor mRNA in chicken intestinal tissues and liver during late embryonic and early posthatching development
2013, Poultry ScienceCitation Excerpt :The expression level in the liver of adult chickens was as low as the levels during the embryonic stage, but 10-fold higher than that in the colon/rectum. The NT precursor mRNA have been identified in mammals such as canine, bovine, and rat by cDNA cloning (Dobner et al., 1987; Kislauskis et al., 1988; Bean et al., 1992) and have been shown to encode neuromedin N (NN) as well as NT in the precursor protein. The nucleotide sequence of chicken NT precursor cDNA has been predicted from the genomic sequence and the amino acid sequence of NT precursor protein encoded in the cDNA has been characterized together with those of other vertebrate species (Hwang et al., 2009).
The potential use of the neurotensin high affinity receptor 1 as a biomarker for cancer progression and as a component of personalized medicine in selective cancers
2011, BiochimieCitation Excerpt :NTS is a tissue-specific gene with a physiological expression pattern restricted to either entero-endocrine N cells, or other cell types like normal epithelial breast cells in the periphery [2,10]. The NTS promoter region was characterized in rats and humans within the proximal 216 bp upstream from the transcription starting site [97–99]. This region included crucial cis-regulating elements that binds both AP-1 (c-Jun, JunD, c-Fos, Fra-1) and CREB/ATF factors [100].
Characterization of promoter elements regulating the expression of the human neurotensin/neuromedin N gene
2011, Journal of Biological ChemistryCitation Excerpt :All cells were maintained in a humidified atmosphere of 95% air and 5% CO2 at 37 °C. A subcloned 0.9-kb EcoRI fragment containing the promoter region of the human NT/N gene (19) was digested with SacI and PvuII and the resulting hNT/N promoter fragment (−373 to +26) was cloned upstream of the luciferase reporter gene in SacI/SmaI-digested pXP1 (19). Deletion mutants for the hNT/N promoter were created using a PCR-based approach.
Neurotensin and growth of normal and neoplastic tissues
2006, Peptides