The regional distribution of sulphonylurea binding sites in rat brain
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Cited by (72)
Mitochondrial K<sup>+</sup> channels and their implications for disease mechanisms
2021, Pharmacology and TherapeuticsCitation Excerpt :Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels were first discovered in the plasma membrane of cardiac myocyte by Noma et al. using single-channel patch-clamp techniques (Noma, 1983). Subsequently, it was established that they are widely expressed in numerous tissues across different animal species, including skeletal muscle (Spruce, Standen, & Stanfield, 1985, 1987), pancreatic β-cells (Ashcroft, Harrison, & Ashcroft, 1984), brain (Treherne & Ashford, 1991; Zawar, Plant, Schirra, Konnerth, & Neumcke, 1999), and kidney (Ho et al., 1993). They are involved in different regulatory functions that include shortening of the action potential duration in cardiac myofibrils, loss of K+ during functional inhibition in heart, regulation of the skeletal muscle excitation, release of insulin by pancreatic β-cell, relaxation of smooth muscle and the release of various neurotransmitters from the neurons of brain parenchyma (Terzic, Jahangir, & Kurachi, 1995; Nelson & Quayle, 1995; Ashcroft & Ashcroft, 1990).
Differential spread of anoxic depolarization contributes to the pattern of neuronal injury after oxygen and glucose deprivation (OGD) in the Substantia Nigra in rat brain slices
2017, NeuroscienceCitation Excerpt :In this respect, the inhibitory response of SNc neurons during the early phase of OGD resembles the effects evoked by anoxia, which were also reduced by a similar dose of tolbutamide as used in our study (Mercuri et al., 1994b; Guatteo et al., 1998a). Indeed, earlier autoradiographic studies demonstrated high expression of sulfonylurea-binding sites in the Substantia Nigra (Mourre et al., 1989; Treherne and Ashford, 1991). Further, functional KATP channel activity was characterized previously in dopaminergic SNc neurons and was shown to be blocked by tolbutamide (100 μM, Liss et al., 1999).
Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone
2017, Experimental NeurologyCitation Excerpt :Inhibition of firing and outward currents evoked by diazoxide were also smaller in LC neurons, indicating that higher expression of KATP channels in nigral DAergic neurons likely contributed to their larger inhibitory responses. This is consistent with previous studies which have demonstrated high KATP channel expression within the Substantia Nigra (Mourre et al., 1989; Treherne and Ashford, 1991). These studies however did not directly compare KATP expression between the SN and LC.
Glibenclamide treatment modulates the expression and localization of myosin-IIB in diabetic rat brain
2014, Journal of the Neurological SciencesCitation Excerpt :In this region of the brain, ATP-K + channels are probably located on presynaptic mossy fibers and there is evidence that sulphonylrea increase the glutamate released from these fibers [61]. Moreover, high-affinity glibenclamide binding sites were found in the brain, especially in the cerebral cortex and hippocampus [62]. These discoveries are important because they indicate a possible regulation mechanism specific to myosin-IIB.
A role for ATP-sensitive potassium channels in male sexual behavior
2009, Hormones and BehaviorK<inf>ATP</inf>-dependent neurotransmitter release in the neuronal network of the rat caudate nucleus
2007, Neurochemistry International
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Present address: Biozentrum der Universita¨t Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.