General Pharmacology: The Vascular System
General paperEvidence for serotonergic system involvement in the effect of morphine on gastrointestinal motility in the rat
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Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon
2010, European Journal of PharmacologyCitation Excerpt :Probably, the remained 5-HT in colon tissue is enough to fulfill the colorectal distension induced sensory reflex; therefore, visceral pain threshold pressure did not demonstrate a significant change in pCPA-treated rats. Previous study on gastrointestinal motility also showed that pCPA treatment (100 mg/kg, 3×) did not affect gastrointestinal transit in rats (Pourgholami and Goshadrou, 1995), and that dosage of pCPA has been proved to induce 65% 5-HT depletion in colon tissue (Koe and Weissman, 1966). Recently, Bertrand et al also proposed that a decrease of 5-HT availability does not cause dramatic gastrointestinal tract dysfunction because the existence of alternative mechanisms, such as the adaptive changes of gastrointestinal tract to the environment and the overlapping functions of numerous gastrointestinal hormones (Bertrand and Bertrand, 2010).
Serotonin release and uptake in the gastrointestinal tract
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2014, European Journal of Pain (United Kingdom)Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut μ<inf>1</inf>-receptor coupled to 5-HT<inf>1A</inf>, D<inf>2</inf>, and GABA<inf>B</inf> systems
2010, American Journal of Physiology - Gastrointestinal and Liver Physiology5-Hydroxytryptamine (5-HT)<inf>2</inf> receptor involvement in acute 5-HT-evoked scratching but not in allergic pruritus induced by dinitrofluorobenzene in rats
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