Clozapine-induced potentiation of synaptic responses in the perforant path-dentate gyrus pathway in chronically prepared rabbits
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Cited by (14)
Clozapine and GABA transmission in schizophrenia disease models: Establishing principles to guide treatments
2015, Pharmacology and TherapeuticsCitation Excerpt :Thus, while clozapine's partial agonist affinity for the serotonin 5-HT1A receptor is unlikely to contribute to a therapeutic mechanism via the local serotonin 5-HT1A receptor, local application of the selective serotonin 5-HT2A receptor antagonist M100907 (100 nM) in a hippocampal slice preparation study reportedly potentiates CA1 LTP (Wang & Arvanov, 1998), suggesting that clozapine's strong antagonist affinity for the serotonin 5-HT2A receptor may at least in part its reported ability to reverse the cognitive deficit. Acute clozapine (20 mg/kg, i.p.) is reported to potentiate the responsiveness of the perforant pathway-DG synapse mediated by a single stimulation prior to LTP, a finding which may contribute at least in part to clozapine's ability to reverse the cognitive deficit (Kubota et al., 1996). Acute clozapine (20 mg/kg, i.p.) is also associated with a 13-fold increase in rat hippocampal pregnenolone levels (Marx et al., 2006) while chronic clozapine (0.33 mg/ml in drinking water, one month, consumption not reported) is associated with a ~15% decrease in local hippocampal kynurenic acid levels (Ceresoli-Borroni et al., 2006).
Effects of antipsychotic D2 antagonists on long-term potentiation in animals and implications for human studies
2014, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Of these six, two found that acute clozapine facilitated LTP (Gemperle et al., 2003; Matsumoto et al., 2008). Three found that clozapine increased EPSP slope and spike amplitude but did not affect the magnitude of potentiation caused by tetanization (Kubota et al., 1996, 2000, 2008), and one found that chronic but not acute clozapine impaired LTP, though this effect was only significant from 50 to 60 min after tetanization (Gemperle and Olpe, 2004). Both studies performed in mutant animals with impaired LTP found that clozapine reversed these deficits (Delotterie et al., 2010; Xu et al., 2009).
Functional and dysfunctional synaptic plasticity in prefrontal cortex: Roles in psychiatric disorders
2011, Psiquiatria BiologicaFunctional and Dysfunctional Synaptic Plasticity in Prefrontal Cortex: Roles in Psychiatric Disorders
2010, Biological PsychiatryEffects of antipsychotics on neuroplasticity: Animal data
2008, EncephaleEffects of zotepine on excitatory synaptic responses in the perforant path-dentate gyrus pathway in chronically prepared rabbits
2002, European Journal of PharmacologyCitation Excerpt :We previously found that clozapine, 20 mg/kg intraperitoneally injected, potentiated the excitatory synaptic responses elicited in the dentate gyrus by single electrical stimulation of the perforant path in chronically prepared rabbits. We called this phenomenon ‘clozapine-induced potentiation’ (Kubota et al., 1996). Further, in a recent study, we found that a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, dizocilpine, at 1.0 mg/kg completely prevented the clozapine-induced potentiation (Kubota et al., 2000).