Pain due to tissue acidosis: a mechanism for inflammatory and ischemic myalgia?
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A role for neuroimmune signaling in a rat model of Gulf War Illness-related pain
2021, Brain, Behavior, and ImmunityCitation Excerpt :As CORT potentiates neuroinflammatory responses (Frank et al., 2015, 2019), high physiological stress is a possible sensitizing factor that could predispose soldiers to GWI in the presence of chemical exposures (Freeman, 2013; Locker et al., 2017). Other factors, such as fatiguing exercise or muscle injury that cause tissue acidosis, could further increase risk of musculoskeletal pain (Gregory et al., 2016; Issberner et al., 1996; Woo et al., 2004). With modifications to induce robust musculoskeletal pain, we examined markers of neuroinflammation and the therapeutic effects of immunomodulatory agents.
Authors' response to the Letter to the Editor on “Clinical consideration in evaluating soreness symptoms of fibromyalgia”
2020, Journal of the Formosan Medical AssociationIschemic Pain
2020, Clinics in Plastic SurgeryAcid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics
2018, NeuroscienceCitation Excerpt :As muscles are fatigued, they release metabolites, including protons and lactate, which can activate nociceptors to produce pain. Acidic saline injected into muscle produces pain and hyperalgesia in healthy adults (Issberner et al., 1996; Frey Law et al., 2008) and hyperalgesia in animals (Hamamoto et al., 1998; Sluka et al., 2001; Gregory et al., 2013). Acid-sensing ion channels (ASICs) are important sensors of protons in muscle sensory neurons (Immke and McCleskey, 2001; Light et al., 2008).