Elsevier

Neuroscience Letters

Volume 205, Issue 1, 16 February 1996, Pages 33-36
Neuroscience Letters

Evidence for modulatory effects of substance P fragments (1–4) and (8–11) on endogenous dopamine outflow in rat striatal slices

https://doi.org/10.1016/0304-3940(96)12363-6Get rights and content

Abstract

The effects of substance P-(1–4) and substance P-(8–11) on endogenous dopamine outflow in rat striatal slices were investigated. The dose-response curves (0.01 nM to 1 μM) were bell-shaped for both peptides, with significant increases in dopamine outflow at 0.1 and 1 nM. Dopamine overflow elicited by 1 nM substance P-(1–4) or substance P-(8–11) and 25 mM KCl was additive. Although substance P-(8–11) contains a truncated tachykinin sequence, the tachykinin NK1 receptor antagonist WIN 51 708 (17β-hydroxy-17α-ethynyl-5α-androstano[3,2-b]pyrimido[1,2-a]benzimidazole (2.5 nM) fully reversed its effect. The interaction between the antagonist and 1 nM substance P-(1–4) was statistically not significant. The data constitute the first evidence that the fragments substance P-(1–4) and substance P-(8–11) could exert central effects and suggest that they may play a role in neuromodulation in the basal ganglia.

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