A 5-hydroxytryptamine lesion markedly reduces the incidence of burst-firing dorsal raphe neurones in the rat☆
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Cited by (30)
Biophysical properties and computational modeling of calcium spikes in serotonergic neurons of the dorsal raphe nucleus
2013, BioSystemsCitation Excerpt :Generally rates around 1 or a few Hz are obtained for spontaneous activity. For five in vivo studies of rat DRN SE cells with sample sizes of more than a few, the following firing rates were reported with various anesthetics for non-bursting activity: 1.42 Hz (n = 27, chloral hydrate), Mosko and Jacobs (1974); 1.2 Hz (n = 31, chloral hydrate), Hájós and Sharp (1996); 1.18 Hz (n = 50, halothane), Kirby et al. (2000); 1.67 Hz (n = 24, urethane), Allers and Sharp (2003) and 2.1 Hz (n = 8, isoflurane followed by urethane), Schweimer and Ungless (2010). Unusually high rates were reported by Kocsis et al. (2006).
Functional organization of the dorsal raphe efferent system with special consideration of nitrergic cell groups
2011, Journal of Chemical NeuroanatomyCitation Excerpt :Initial explorations of DRN topography and physiology suggested that the principal role of the nucleus was to provide for nearly simultaneous release of 5HT throughout multiple forebrain structures (Jacobs and Fornal, 1991, 1999; McQuade and Sharp, 1995; Wilkinson and Jacobs, 1988). However, more recent anatomical and electrophysiological investigations have generated data which challenge the notion that the DRN is structured solely for a global mode of operation (Hajos et al., 1995; Hajos and Sharp, 1996; Kirifides et al., 2001; Lowry, 2002; Lowry et al., 2005; Varga et al., 2003; Waselus et al., 2006; Waterhouse et al., 1986a, 1990, 1993; Wilson and Molliver, 1991), and have demonstrated a role for the non-5HT component of the DRN in the stress response, particularly within the lateral wing subregion of the nucleus (Okere and Waterhouse, 2006a, 2006b; Roche et al., 2003). This review serves to summarize results from our laboratories and others that argue for anatomical, neurochemical, and functional order within the DRN efferent system.
Neural and Cardiac Toxicities Associated With 3,4-Methylenedioxymethamphetamine (MDMA)
2009, International Review of NeurobiologySelective anterograde tracing of the individual serotonergic and nonserotonergic components of the dorsal raphe nucleus projection to the vestibular nuclei
2007, NeuroscienceCitation Excerpt :A burr hole was drilled in the cranium, and a solution of 7.5% BDA (10,000 MW; Molecular Probes, Eugene, OR, USA) in 10 mM phosphate-buffer containing 0.5 M NaCl, pH 7.0, was injected iontophoretically (4 μA positive pulsed square wave, 15 s duty cycle, 15 min on-time) into DRN using glass micropipettes (∼40 μm tip diameter). A 14-day post-5,7-DHT survival period (i.e. 7 days after BDA injection) was used because it produces a profound loss of markers for serotonergic DRN cells (Serrats et al., 2005; Hajós and Sharp, 1996; Bendotti et al., 1990). After a 7-day survival period, rats were killed with sodium pentobarbital (100 mg/kg, i.p.), and perfused transcardially with phosphate-buffered saline (PBS; 0.9% NaCl in 50 mM phosphate-buffer, pH 7.3) followed by paraformaldehyde–lysine–periodate fixative (10% paraformaldehyde, 75 mM l-lysine, 10 mM sodium periodate, and 40 mM sucrose in 50 mM phosphate-buffer, pH 7.4; McLean and Nakane, 1974).
Ozone exposure alters 5-hydroxy-indole-acetic acid contents in dialysates from dorsal raphe and medial preoptic area in freely moving rats. Relationships with simultaneous sleep disturbances
2003, Chemico-Biological InteractionsCitation Excerpt :In vivo microdialysis studies have demonstrated that extracellular levels of 5-HT in the DR are raised during wakefulness (W), they reach an intermediate concentration during SWS and are lowest during PS [15]. Biochemical studies have supported the sleep modulatory role of 5-HT in the DR using either specific serotonergic lesions in rats [16] or in vivo microdialysis techniques in freely moving cats [17]. Electrical stimulation of the DR produces an increase in 5-hydroxyindole compounds in the hypothalamus and a state of alert wakefulness followed by a PS rebound in rats [18].
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This work was supported by the Medical Research Council (UK).