AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells

doi:10.1016/0304-3940(95)12029-4

Neuroscience Letters

Volume 199, Issue 2, 20 October 1995, Pages 131-134

https://doi.org/10.1016/0304-3940(95)12029-4 Get rights and content

Abstract

AIT-082 is a novel, metabolically stable, derivative of the purine hypoxanthine. Addition of AIT-082 to cultured PC12 cells enhanced significantly nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. These results suggest a cellular mechanism, the enhancement of NGF-action, that might account for the ability of AIT-082 to restore age-induced working memory deficits in mice.

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AIT-082, a unique purine derivative, enhances nerve growth factor mediated neurite outgrowth from PC12 cells

Abstract

Pharm. Biochem. Behav.

Adv. Cell. Neurobiol.

Exp. Neurol.

Med. Hypotheses

Med. Hypotheses

Neurosci. Res.

Behav. Brain Res.

Stimulation of astrocyte proliferation by purine and pyrimidine nucleotides and nucleotides

Glia