Nanomolar concentrations of nicotine increase the release of [3H]dopamine from rat striatal synaptosomes
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Differential nicotinic regulation of the nigrostriatal and mesolimbic dopaminergic pathways: Implications for drug development
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2005, Brain Research ReviewsComparison of the effects of nicotine and epibatidine on the striatal extracellular dopamine
2004, European Journal of PharmacologyCitation Excerpt :There is evidence that nicotinic receptors composed of different subunits differ in their pharmacological properties, and also that they are differentially distributed in the brain, which makes it more complicated to develop selective ligands with desired therapeutic properties. Nicotine stimulates dopamine release in the brain, as seen in vitro with striatal, accumbal and frontal cortical slices and synaptosomes (Westfall, 1974; Giorguieff-Chesselet et al., 1979; Sakurai et al., 1982; Rapier et al., 1988; Rowell, 1995; Whiteaker et al., 1995; Teng et al., 1997) and by indirect evidence in vivo (Nose and Takemoto, 1974; Lichtensteiger et al., 1982). Acute systemically administered nicotine has been found to facilitate dopamine output in vivo in numerous microdialysis studies (Imperato et al., 1986; Di Chiara and Imperato, 1988; Damsma et al., 1989; Benwell and Balfour, 1992; Mirza et al., 1996; Nisell et al., 1996; Benwell and Balfour, 1997; Seppa and Ahtee, 2000; Seppa et al., 2000).