Elsevier

Neuroscience Letters

Volume 165, Issues 1–2, 3 January 1994, Pages 211-214
Neuroscience Letters

Enhancement of NMDA toxicity and calcium responses by chronic exposure of cultured cortical neurons to ethanol

https://doi.org/10.1016/0304-3940(94)90747-1Get rights and content

Abstract

Exposure of rat cerebrocortical cultures to 100 mM ethanol for 3-4 days increased both the neurotoxic potency of N-methyl-d-aspartate (NMDA) and the maximal extent of NMDA-induced intracellular calcium (Ca2+i) elevations. In both control and ethanol-treated cultures, NMDA toxicity correlated closely with [Ca2+]i. Enhancement of NMDA responses may reflect neuronal adaptation to chronic ethanol exposure and could contribute to the pathogenesis of alcohol-related neurologic disorders.

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