Elsevier

Neuroscience Letters

Volume 178, Issue 1, 29 August 1994, Pages 90-94
Neuroscience Letters

Bi-directional effects of intrathecal NMDA and substance P on rat dorsal horn neuronal responses

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Abstract

Intrathecal NMDA (5 ng) facilitated wind-up but not C-fibre evoked responses, whereas 50 ng facilitated C-fibre and Aδ-fibre evoked responses but not wind-up of convergent dorsal horn neurones in the halothane anaesthetized rat. Higher doses of NMDA and SP (10–500 ng) were without effect. Co-administered SP (10 ng) with NMDA (5 ng) facilitated Aδ-fibre evoked responses and wind-up. Excitatory amino acid and peptide interactions are discussed.

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