Elsevier

Neuroscience Letters

Volume 163, Issue 2, 12 December 1993, Pages 155-158
Neuroscience Letters

Anti-glutamatergic effects of clozapine

https://doi.org/10.1016/0304-3940(93)90370-ZGet rights and content

Abstract

Clozapine (Cz) is unique in its efficacy with treatment refractory patients and its freedom from motor side effects. The present work shows that Cz, even after dopamine depletion, suppresses responses evoked via the monosynaptic glutamatergic corticostriatal pathway. In addition, Cz is effective in displacing [3H]MK-801 from striatal homogenates. These data indicate that Cz is a glutamate antagonist. It is unclear, however, if this pharmacological action could explain Cz's lack of motor effects and it's antipsychotic potency.

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