Anti-glutamatergic effects of clozapine
References (29)
- et al.
Interactions between glutamatergic and monoaminergic systems within the basal ganglia - implications for schizophrenia and Parkinson's disease
Trends Neurosci.
(1990) - et al.
Modification of evoked responses in the caudate nucleus by cholinergic agents
Neuropharmacology
(1976) - et al.
Clozapine's mechanisms of action: non-dopaminergic activity rather than anatomical selectivity
Neurosci. Lett.
(1992) Application of high performance liquid chromatography with electrochemical detection to neurochemical analysis: measurement of catecholamines, serotonin and metabolites in rat brain
J. Neurosci. Methods
(1981)Developments in the drug treatment of schizophrenia
Trends Pharmacol. Sci.
(1992)- et al.
Effects of l-glutamate and related amino acids upon the release of [3H]dopamine from rat striatal slices
Neuropharmacology
(1978) Antagonism of cortical excitation of striatal neurons by glutamic acid diethylester: evidence for glutamic acid as an excitatory transmitter in the rat striatum
Brain Res.
(1976)- et al.
The corticostriatal projection in the cat: relation between axon terminals and evoked potentials
Brain Res.
(1987) - et al.
Midbrain dopamine system electrophysiological functioning: a review and new hypothesis
Synapse
(1991) - et al.
Neuroleptic medications inhibit complex I of the electron transport chain
Ann. Neurol.
(1993)
Burst firing of mesencephalic dopamine neurons is inhibited by somatodendritic application of kynurate
Acta Physiol. Scand.
(1991)
Neuroleptic-induced catalepsy as a model of Parkinson's disease II. Effect of glutamate antagonists
J. Neural Transm.
(1990)
The thyroid gland
Dose-related plasma levels of clozapine
J. Clin. Psychopharm.
(1989)
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2011, Pharmacology Biochemistry and BehaviorCitation Excerpt :Thus, animals treated with moderate doses of NMDA receptor antagonists, such as PCP, ketamine, or MK801, are used to model various aspects of schizophrenia; these animals exert schizophrenia symptoms, including hyperlocomotion, enhanced stereotypic behaviors, cognitive and sensorimotor gating deficits, and impaired social interactions (Lipska and Weinberger, 2000). Atypical antipsychotics exert differential effects on the NMDA receptor, in comparison to classical agents (Lidskey et al., 1993), and chronic antipsychotic drug treatment alters mRNA expression of NMDA receptor subunits. In recent studies, olanzapine has been shown to increase ACh release via blockade of terminal muscarinic M2 receptors (Johnson et al., 2005).
Atypical antipsychotics attenuate a sub-chronic PCP-induced cognitive deficit in the novel object recognition task in the rat
2007, Behavioural Brain ResearchClozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine
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2006, Progress in Neuro-Psychopharmacology and Biological Psychiatry
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