Antinociception from the administration of β-endorphin into the periaqueductal gray of rat is enhanced while that of morphine is inhibited by barbiturate anesthesia
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Cited by (16)
Barbiturates enhance itch-associated scratching in atopic dermatitis mice: A possible clue to understanding nocturnal pruritus in atopic dermatitis
2018, European Journal of PharmacologyCitation Excerpt :Several studies suggest that periaqueductal gray plays a critical role in modulating itch as well as pain (Carstens, 1997; Mochizuki et al., 2003; Papoiu et al., 2013). Notably, it has been reported that electrical stimulation-induced neural activity in the periaqueductal gray was attenuated by pentobarbital or the L-VDCC antagonist verapamil (Schenberg et al., 2000; Smith et al., 1992). Furthermore, glutaminergic neurons descending from the periaqueductal gray to the rostral ventromedial medulla or the locus coeruleus and the AMPA glutamate receptors have been demonstrated to significantly contribute to pain modulation (Ennis et al., 1992; Lau and Vaughan, 2014; Spinella et al., 1996).
Affective analgesia following the administration of morphine into the amygdala of rats
2003, Brain ResearchCitation Excerpt :McGaraughty and Heinricher [75] also reported increases in tail-flick latencies in barbiturate-anesthetized rats following the injection of morphine into the BLC. However, barbiturate anesthesia reportedly modifies the antinociceptive action of intracerebrally administered opiates in the tail-flick test [82,102]. Whether barbiturate anesthesia modifies the antinociceptive action of opiates administered into the amygdala has not been directly tested.
Evidence for ε-opioid receptor-mediated β-endorphin-induced analgesia
2001, Trends in Pharmacological SciencesAnalysis of sex and gonadectomy differences in β-endorphin antinociception elicited from the ventrolateral periaqueductal gray in rats
2000, European Journal of Pharmacology