Pertussis toxin-sensitive G-protein mediates galanin's inhibition of scopolamine-evoked acetylcholine release in vivo and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus
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Performance of galanin transgenic mice in the 5-choice serial reaction time attentional task
2006, Pharmacology Biochemistry and BehaviorCitation Excerpt :The inhibition of central cholinergic function by galanin is evident in studies from several different levels of analysis. On the biochemical level, galanin inhibited carbachol-stimulated PI hydrolysis (Consolo et al., 1991; Palazzi et al., 1991). In physiological studies using slice preparations of the hippocampus, galanin blocked the slow excitatory post-synaptic potential induced by acetylcholine in CA1 pyramidal neurons (Dutar et al., 1989).
Galanin and galanin receptors in epilepsy
2004, NeuropeptidesPatterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice
2004, NeuroscienceCitation Excerpt :Galanin coexists with acetylcholine in septum/diagonal band complex, an area which sends cholinergic/galaninergic projections to the hippocampus (Melander et al., 1986; Consolo et al., 1994). In the hippocampus galanin inhibits both acetylcholine release (Dutar et al., 1989; Fisone et al., 1987), and postsynaptic cholinergic functions (Consolo et al., 1991). Inactivation of GalR1 in KO mice may facilitate both acetylcholine release and postsynaptic effects of pilocarpine and acetylcholine, thus promoting both components which contribute to the development of Li-pilocarpine SE.
Pharmacological evidence supporting a role for galanin in cognition and affect
2001, Progress in Neuro-Psychopharmacology and Biological PsychiatryGalanin antagonizes vasopressin-stimulated flank marking in male golden hamsters
1999, Brain Research