Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus
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2023, Neuroscience and Biobehavioral ReviewsNeurophysiological basis of the N400 deflection, from Mismatch Negativity to Semantic Prediction Potentials and late positive components
2021, International Journal of PsychophysiologyCitation Excerpt :Interestingly, these functions were delivered precisely by agonism of M1 receptors. Resemblant scenarios of layer I excitation and dendritic plateaus with somata quiescence have been observed elsewhere, especially during long-term potentiation (Gambino et al., 2014; Williams and Holtmaat, 2019), which relies heavily on, and is enhanced by, acetylcholine and VIP activation (e.g., Blitzer et al., 1990 see also Krabbe et al., 2019). Evidence suggests that dendritic plateaus occur for a similar duration as the N4 as well.
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2020, Current Opinion in PhysiologyAcetylcholine and the complex interdependence of memory and attention
2020, Current Opinion in Behavioral SciencesCitation Excerpt :In fact, acetylcholine suppresses excitatory transmission from CA3 to CA1 [42] (Figure 2), and manipulations thought to increase acetycholine release similarly shift the strength of different CA1 inputs [43]. Although acetylcholine reduces the driving force of CA3 input, it facilitates LTP between active CA3 and CA1 neurons [44,45] and, in doing so, could promote new memory encoding. In summary, the combined effects of cholinergic modulation in the hippocampus are highly suggestive of a mode switching function, biasing the hippocampus toward encoding distinctive memories during periods of high innervation and reactivating stored memory traces during periods of low innervation.
Hippocampus-dependent fear conditioning is not sensitized by muscarinic receptor activation following systemic injection of pilocarpine
2019, Neurology Psychiatry and Brain ResearchCitation Excerpt :Associative learning is closely related to synaptic plasticity, and LTP properties, such as fast induction and associativity, are pointed as ideal candidates in the codification of aversive memories (Maren, 2005). There is broad evidence showing the regulatory action of the cholinergic system on hippocampal-dependent memory (Auerbach & Segal, 1994; Blitzer, Gil, & Landau, 1990; Shinoe, Matsui, Taketo, & Manabe, 2005), an effect possibly modulated by M1 subtype mAChRs (Boddeke, Enz, & Shapiro, 1992; Burgard & Sarvey, 1990). However, M1 null mutant mice display only mild impairment of learning and hippocampal LTP (Anagnostaras et al., 2003).
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