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Cited by (60)
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia
2013, NeuroscienceCitation Excerpt :Another possible explanation for the hyperalgesia that remained after SSP–SAP treatment is local segmental sensitization in the spinal cord. The ability of spinal neurons to become sensitized without involvement of supraspinal modulation has been shown in spinalized animals (Woolf and King, 1990; Wang et al., 2001; Seybold et al., 2003; Molina and Herrero, 2006; Yamamoto et al., 2013) as well as in the isolated spinal cord in vitro (Woolf and King, 1987; King et al., 1988a,b, 1990; Woolf et al., 1988). It was suggested that the RVM plays a modulating rather than a permissive role in its influence on responsiveness of nociceptive spinal neurons (Foo and Mason, 2003; Jinks et al., 2004).
Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing
2005, NeuropharmacologyCitation Excerpt :The persistent release of glutamate in pain pathways can lead to the development of central sensitization, characterized by altered responsiveness of dorsal horn and thalamic neurons, expansion of receptive fields, and plasticity of neuronal connections (e.g., Woolf et al., 1994; Coderre, 1993; Urban et al., 1994; Salt and Eaton, 1995). Further, repetitive C-fiber stimulation produces a “wind-up” of dorsal horn neuron activity that is mimicked by the application of l-glutamate (Zieglgansberger and Herz, 1971) and NMDA (King et al., 1988). Blockade of the activation of post-synaptic ionotropic (e.g., Coderre and van Empel, 1994) as well as group I metabotropic receptors, located either post-synaptically in the brain or on peripheral, unmyelinated fibers (e.g., Moroni et al., 1997; Young et al., 1997; Bhave et al., 2001; see also review Varney and Gereau, 2002) has been shown to produce antinociception and decrease central sensitization.
Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test
2001, Experimental Neurology
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Present address: Department of Anatomy, University Medical School, University of Debrecen, Debrecen, Hungary.