A morphogenic role for transiently expressed acetylcholinesterase in developing thalamocortical systems?
References (23)
- et al.
Acetylcholinesterase hydrolyzes substance P
Neuroscience
(1980) The organization and some projections of cholinergic neurons of the mammalian forebrain
Brain Res. Rev.
(1982)Acetylcholinesterase may have novel functions in the brain
Trends Neurosci.
(1984)Acetylcholinesterase in the ventrobasal thalamus: transience and patterning during ontogenesis
Neuroscience
(1983)- et al.
Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons
Neuroscience
(1984) - et al.
Cholinergic innervation displays strikingly different laminar preferences in several cortical areas
Neurosci. Lett.
(1986) - et al.
An autoradiographic study of the projections from the lateral geniculate body of the rat
Brain Res.
(1975) - et al.
Transient patterns of acetylcholinesterase activity in visual cortex of the rat: normal development and the effects of neonatal monocular enucleation
Dev. Brain Res.
(1985) Thalamic and callosal connections of the rat auditory cortex
Brain Res.
(1983)Acetylcholinesterase histochemistry
Handb. Chem. Neuroanat.
(1983)
Histochemical distribution of acetylcholinesterase in the central nervous system: clues to the localization of cholinergic neurons
Handb. Chem. Neuroanat.
Cited by (141)
Cholinesterases and the fine line between poison and remedy
2018, Biochemical PharmacologyCitation Excerpt :A number of studies suggest that both cholinesterases have non-catalytic roles in neurodevelopment, possibly playing a “morphogenic” role in vertebrate systems [112–116]. Some of the most striking findings in support of a morphogenic role for the cholinesterases include the spatiotemporal expression patterns of AChE in the thalamocortical and geniculocortical projections during neonatal rat brain development [113,117]. These neurons are not cholinergic nor do they receive cholinergic innervation in adulthood, but during a discrete window of development (peaking during week 2 of postnatal development correlating with the timing of respective fiber ingrowth into the cortex) they exhibit intense AChE staining.
Developmental toxicity within the central cholinergic nervous system
2018, Handbook of Developmental NeurotoxicologyMicrotubule-associated targets in chlorpyrifos oxon hippocampal neurotoxicity
2007, NeuroscienceCitation Excerpt :Clearly, some adverse effects of CPF or CPO exposure, particularly during CNS development, may involve consequences of marked AChE inhibition. For example, AChE clearly has an extrasynaptic morphogenic role in neurite development and its inhibition attenuates neurite growth as well as recovery from axotomy (Robertson, 1987; Dupree et al., 1995; Dupree and Bigbee, 1994). In contrast, others have shown that CPF exposure produces abnormalities in axonal and dendritic growth in developing sympathetic neurons at concentrations far below those that inhibit AChE (Howard et al., 2005).
Can cholinesterase inhibitors affect neural development?
2005, Environmental Toxicology and PharmacologyDevelopmental toxicity study of chlorpyrifos in rats
2003, Reproductive ToxicologyRescue of the acetylcholinesterase knockout mouse by feeding a liquid diet; phenotype of the adult acetylcholinesterase deficient mouse
2002, Developmental Brain Research