Antagonism of non-cholinergic excitatory junction potentials in the guinea-pig ileum by a substance P analogue antagonist
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2014, Pharmacology and TherapeuticsCitation Excerpt :Purinergic IJPs are significantly attenuated, while the slow nitrergic IJPs remain intact in experimental models of colitis (Strong et al., 2010; Roberts et al., 2013), suggesting that aberrant purinergic neurotransmission might contribute to motility disorders in disease states. The fast IJPs are sensitive to apamin (Taylor & Bywater, 1986; Bridgewater et al., 1995; Rae & Muir, 1996; Spencer et al., 1998b; Gallego et al., 2006; Mutafova-Yambolieva et al., 2007) and are therefore coupled to the opening of SK channels. The fast IJPs are also mediated by the P2Y1 receptor, because they are inhibited by selective P2Y1 receptor antagonists (Gallego et al., 2006; Mutafova-Yambolieva et al., 2007; Wang et al., 2007; Gallego et al., 2008b; Hwang et al., 2011) and absent in colonic preparations from P2ry1−/− mice (Gallego et al., 2012; Hwang et al., 2012).
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