Elsevier

Neuroscience Letters

Volume 20, Issue 3, December 1980, Pages 379-382
Neuroscience Letters

Low cerebrospinal fluid glutamate in schizophrenic patients and a new hypothesis on schizophrenia

https://doi.org/10.1016/0304-3940(80)90178-0Get rights and content

Abstract

In the cerebrospinal fluid of 20 schizophrenic patients the glutamate level was found to be about half the normal value, whereas the serum glutamate was not altered. Preliminary evidence indicates that this reduced glutamate content is not due to neuroleptic treatment. The glutamate decrease is interpreted by the hypothesis that there is a dysfunction or degeneration of glutamatergic neurons in schizophrenia.

References (11)

There are more references available in the full text version of this article.

Cited by (595)

  • Commentary on Monoamine oxidase and its inhibitors in relation to antidepressive activity by E. Albert Zeller

    2022, Discoveries in Pharmacology - Volume 1 - Nervous system and hormones
  • Taurine prevents MK-801-induced shoal dispersion and altered cortisol responses in zebrafish

    2021, Progress in Neuro-Psychopharmacology and Biological Psychiatry
View all citing articles on Scopus
View full text