Peroxisome proliferator-activated receptors: finding the orphan a home
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Biocatalytic one pot three component approach: Facile synthesis, characterization, molecular modelling and hypoglycemic studies of new thiazolidinedione festooned quinoline analogues catalyzed by alkaline protease from Aspergillus niger
2022, Bioorganic ChemistryCitation Excerpt :Thiazolidinediones (TZDs) reduces the resistance towards insulin directly through the activation of peroxisome proliferator activated receptor gamma (PPARγ) which is a part of nuclear receptor family [44]. PPARγ accelerates the differentiation of mesenchymal stem cells into adipocytes, reduces the peripheral and hepatic triglycerides, alters the expression of genes that are also controlled by insulin and stimulate lipogenesis in pheripheral adipocytes [45-49]. 2,4-Thiazolidinedione and its derivatives signify the most encouraging group of structural compounds having a widespread pharmacological importance especially as PPARγ agonists [50].
Ultrasound promoted montmorillonite K-10 catalyzed synthesis, characterization, molecular modelling, SAR and hypoglycemic studies of new rhodanine bejeweled acridine analogues
2021, Journal of Molecular StructureCitation Excerpt :Thiazolidinediones (TZDs) reduces the resistance towards insulin directly through the activation of peroxisome proliferator activated receptor gamma (PPARγ) which is a part of nuclear receptor family [41]. PPARγ accelerates the differentiation of mesenchymal stem cells into adipocytes, reduces the peripheral and hepatic triglycerides, alters the expression of genes that are also controlled by insulin and stimulate lipogenesis in pheripheral adipocytes [42-46] (Fig. 2). Rhodanine derivatives have been shown to reduce plasmatic glucose, lipid and insulin levels and can be used for treatment of the diabetes mellitus type-2 similar to thiazolidinediones [47].
Distinct m<sup>6</sup>A methylome profiles in poly(A) RNA from Xenopus laevis testis and that treated with atrazine
2020, ChemosphereCitation Excerpt :Peroxisome proliferator-activated receptors (PPAR) signaling pathway was included in the KEGG result of differentially expression m6A related mRNAs (Fig. 3b). PPAR is a pathway that can maintain the energy homeostasis of germ cells (Harada et al., 2016; Green and Wahli, 1994). There is evidence that Di (n-butyl phthalate), as a PPAR activator, can regulate the expression of spermatogenesis related genes and induce testicular atrophy in rats (Ryu et al., 2007).
Lipid oxidation products in the pathogenesis of non-alcoholic steatohepatitis
2017, Free Radical Biology and MedicineCitation Excerpt :HNE may affect lipid metabolism via signal transduction and gene expression, mostly by the regulation of peroxisome proliferator-activated receptors (PPARs). These NRs are activated by peroxisome proliferators, a miscellaneous group of rodent hepatocarcinogens that include hypolipidemic drugs, plasticizers, and herbicides; in vertebrates, four PPAR isoforms termed α, γ, and β/δ are described [203]. PPARα induces genes involved in mitochondrial, peroxisomal, and microsomal FA oxidation [204–206].
Thiazolidine-2,4-diones as multi-targeted scaffold in medicinal chemistry: Potential anticancer agents
2014, European Journal of Medicinal ChemistryCitation Excerpt :Upon ligand binding, the complex of PPAR and RXR binds to specific recognition sites on DNA, the peroxisome proliferator response elements (PPREs) and regulates transcription of specific genes [30–35]. A PPRE, consisting of an almost perfect direct repeat of the sequence TGACCT spaced by a single base pair, has been identified in the upstream regulatory sequences of genes related to metabolic pathways [36]. The PPAR-γ and RXR complex, along with other co-activators for transcription formed heterodimer complex, activate transcription of target genes [37].
Activation of PPAR α and PPAR β/δ regulates Sertoli cell metabolism
2014, Molecular and Cellular Endocrinology