The cloning of the human follicle stimulating hormone receptor and its expression in COS-7, CHO, and Y-1 cells
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2015, Environment InternationalCitation Excerpt :These factors explain why there are no widely reported standardized assays for characterizing the effects of chemicals on the FSHR. However, recombinant human FSHR have been successfully transfected into both rodent (Kelton et al., 1992; Christin-Maitre and Bouchard, 1996) and human (HEK293) cells (Karakaya et al., 2014). Both LHR and FSHR are expressed on some human cancer cell lines such as OCC1, and this cell line proliferates in response to stimulation by FSH or hCG (Parrott et al., 2001), thus providing a potential assay of in vitro physiological response for agonism or antagonism at these receptors.
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2014, Molecular and Cellular EndocrinologyCitation Excerpt :Indeed, thyrostimulin, which lacks a putative ‘seatbelt’ loop, is not as stable as the other GPHs (Okajima et al., 2008). The advances in cloning and expression of glycoprotein hormone receptors (GPHRs) since 1989 (Kelton et al., 1992; McFarland et al., 1989; Parmentier et al., 1989; Sprengel et al., 1990) initiated a period of rapid progress in understanding and ultimately providing reagents which would lead to the structural evidence for the mode of interaction of GPH ligands with their receptors. An imperfect motif of leucine-rich repeats (LRRs) in the sequence of the ectodomain of LHR identified by McFarland and coworkers led to the proposal that the ectodomain contains 14 LRRs (McFarland et al., 1989).
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