Neurochemical modulation of cardiovascular control in the nucleus tractus solitarius

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Abstract

The central control of cardiovascular function has been keenly studied for a number of decades. Of particular interest are the homeostatic control mechanisms, such as the baroreceptor heart-rate reflex, the chemoreceptor reflex, the Bezold-Jarisch reflex and the Breuer-Hering reflex. These neurally-mediated reflexes share a common termination point for their respective centrally-projecting sensory afferents, namely the nucleus tractus solitarius (NTS). Thus, the NTS clearly plays a critical role in the integration of peripherally initiated sensory information regarding the status of blood pressure, heart rate and respiratory function. Many endogenous neurochemicals, from simple amino acids through biogenic amines to complex peptides have the ability to modulate blood pressure and heart rate at the level of the NTS. This review will attempt to collate the current knowledge regarding the roles of neuromodulators in the NTS, the receptor types involved in mediating observed responses and the degree of importance of such neurochemicals in the tonic regulation of the cardiovascular system. The neural pathway that controls the baroreceptor heart-rate reflex will be the main focus of attention, including discussion of the identity of the neurotransmitter(s) thought to act at baroafferent terminals within the NTS. In addition, this review will provide a timely update on the use of recently developed molecular biological techniques that have been employed in the study of the NTS, complementing more classical research.

References (447)

  • R.A. Barraco et al.

    Cardiovascular effects of microinjection of adenosine analogs into the fourth ventricle of rats

    Brain Res.

    (1987)
  • R.A. Barraco et al.

    Cardiovascular effects of microinjections of adenosine into the nucleus tractus solitarius

    Brain Res. Bull.

    (1988)
  • R.A. Barraco et al.

    Respiratory effects of 5′-ethylcarboxamidoadenosine, an analogue of adenosine, following microinjections into the nucleus tractus solitarius of rats

    Brain Res.

    (1989)
  • R.A. Barraco et al.

    The adenosine analog, 5′-N-ethylcarboxamidoadenosine, exerts mixed agonists actions on cardiorespiratory parameters in the intact but not decerebrate rat following microinjections into the nucleus tractus solitarius

    Brain Res.

    (1990)
  • R.A. Barraco et al.

    Cardiorespiratory response patterns elicited by microinjection of neuropeptide-Y in the nucleus tractus solitarius

    Brain Res. Bull.

    (1990)
  • R.A. Barraco et al.

    Cardiorespiratory function is altered by picomole injections of 5′-N-ethylcarboxamidoadenosine into the nucleus tractus solitarius of rats

    Brain Res.

    (1990)
  • R.A. Barraco et al.

    Subtypes of adenosine receptors in the brainstem mediate opposite blood pressure responses

    Neuropharmacol.

    (1991)
  • R.A. Barraco et al.

    Adenosine receptor subtypes in the brainstem mediate distinct cardiovascular response patterns

    Brain Res. Bull.

    (1991)
  • R.A. Barraco et al.

    Y2 Receptors for neuropeptide-Y in the nucleus of the solitary tract mediate depressor responses

    Peptides

    (1991)
  • R.A. Barraco et al.

    An atlas of the rat subpostremal nucleus tractus solitarius

    Brain Res. Bull.

    (1992)
  • P.M. Beart et al.

    Excitatory amino acid projections to the nucleus of the solitary tract in the rat: a retrograde transport study utilizing D-[3H]aspartate and [3H]GABA

    J. Auton. Nerv. Sys.

    (1994)
  • J.C. Bisserbe et al.

    Autoradiographic localization of adenosine uptake sites in guinea-pig brain using [3H]dipyridamole

    Neurosci. Lett.

    (1986)
  • W.W. Blessing et al.

    Glutamic acid decarboxylase immunoreactivity is present in perikarya of neurons in nucleus tractus solitarius of rat

    Brain Res.

    (1984)
  • W.W. Blessing et al.

    Transneuronal transport of herpes simplex virus from the cervical vagus to brain neurons with axonal inputs to central vagal sensory nuclei in the rat

    Neuroscience

    (1991)
  • B. Bonaz et al.

    Peripheral bombesin induces c-fos protein in the rat brain

    Brain Res.

    (1993)
  • B. Bonaz et al.

    Peripheral peptide YY induces c-fos-like immunoreactivity in the rat brain

    Neurosci. Lett.

    (1993)
  • J.B. Boone et al.

    Differential effects of prolonged restraint stress on proenkephalin gene expression in the brainstem

    Mol. Brain Res.

    (1994)
  • M. Castillo-Meléndez et al.

    Presynaptic adenosine A2a receptors on soma and central terminals of rat vagal afferent neurons

    Brain Res.

    (1994)
  • J.M. Catelli et al.

    Enhanced response to GABA in the nucleus tractus solitarii of the spontaneously hypertensive rat

    Eur. J. Pharmacol.

    (1988)
  • J.M. Catelli et al.

    GABAergic mechanisms in nucleus tractus solitarius alter blood pressure and vasopressin release

    Brain Res.

    (1987)
  • S. Ceccatelli et al.

    Presence of a dynorphin-like peptide in a restricted subpopulation of catecholaminergic neurons in rat nucleus tractus solitarii

    Brain Res.

    (1992)
  • J.Y.H. Chan et al.

    Reversal by pertussis toxin and N-ethylmaleimide of the facilitation of baroreceptor reflex response by somatostatin in the rat

    Neurosci. Lett.

    (1992)
  • J.Y.H. Chan et al.

    Participation of endogenous neuropeptide Y in the suppression of baroreceptor reflex response by locus coeruleus in the rat

    Reg. Pep.

    (1993)
  • E.S. Corp et al.

    Characterization of type A and type B CCK receptor binding sites in rat vagus nerve

    Brain Res.

    (1993)
  • L. Criscione et al.

    Cholinergic mechanisms in the nucleus tractus solitarii and cardiovascular regulation in the rat

    Eur. J. Pharmacol.

    (1983)
  • M.F. Czyzyk-Krzeska et al.

    Expression of messenger RNAs for peptides and tyrosine hydroxylase in primary sensory neurons that innervate arterial baroreceptors and chemoreceptors

    Neurosci. Lett.

    (1991)
  • W.D. Dietrich et al.

    The distribution of glutamate, GABA and aspartate in the nucleus tractus solitarius of the cat

    Brain Res.

    (1982)
  • Y.-F. Duan et al.

    Modulation of neuronal firing in the medullary solitary complex by electrical stimulation of the hypothalamic defense and vigilance areas in rabbits

    Brain Res.

    (1994)
  • E. Ergene et al.

    Activation of P2-purinoceptors in the nucleus tractus solitarius mediate depressor responses

    Neurosci. Lett.

    (1994)
  • E. Ergene et al.

    Visceroendocrine responses elicited by neuropeptide Y in the nucleus tractus solitarius

    Brain Res. Bull.

    (1993)
  • R. Ermirio et al.

    Cardiovascular effects of microinjection of atrial natriuretic factor (ANF) in the nucleus tractus solitarii of spontaneously hypertensive rats

    J. Auton. Nerv. Sys.

    (1994)
  • L. Fan et al.

    Cardiovascular effects of microinjection of dynorphin fragments into the nucleus of the solitary tract (NTS) are mediated by non-opioid mechanisms

    Brain Res.

    (1993)
  • P.D. Feldman et al.

    α-Adrenergic influences on neuronal responses to visceral afferent input in the nucleus tractus solitarius

    Neuropharmacol.

    (1989)
  • P.D. Feldman et al.

    Effects of γ-aminobutyric acid and glycine on synaptic excitability of neurones in the solitary tract nucleus

    Neuropharmacol.

    (1991)
  • S.J. Fidone et al.

    Mechanisms od chemotransmission in the mammalian carotid body

    Prog. Brain Res.

    (1988)
  • J.C.W. Finley et al.

    Transmitter diversity in carotid body afferent neurons: dopaminergic and peptidergic phenotypes

    Neuroscience

    (1992)
  • D.R. Fior et al.

    Autoradiographic evidence for a bradykinin/angiotensin II receptor-receptor interaction in the rat brain

    Neurosci. Lett.

    (1993)
  • D.R. Fior et al.

    Bradykinin modulation of α2-adrenoceptors in the nucleus tractus solitarii of the rat. An in vitro autoradiographical study

    Neuropharmacol.

    (1995)
  • A. Florentino et al.

    Mechanism of the cardiovascular effects of GABAB receptor activation in the nucleus tractus solitarii of the rat

    Brain Res.

    (1990)
  • F.M. Abboud et al.

    Sensitization of aortic and cardiac baroreceptors by arginine vasopressin in mammals

    J. Physiol., Lond.

    (1986)
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