Apoptosis in the developing CNS
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Cited by (103)
Peptidase neurolysin is an endogenous cerebroprotective mechanism in acute neurodegenerative disorders
2019, Medical HypothesesCitation Excerpt :It is noteworthy that the pattern of developmental changes in the expression of Nln is very similar to the occurrence of neuronal death in developing brain [20]. The number of dead neurons in rat cerebral cortex is low at birth, which increases from P2, peaking at the end of the first week, and decreases during the second week followed by low numbers at the end of the first month [20]. These in vivo observations complement the above discussed data and support the association between neuronal cell death and Nln.
Insulin-like growth factor 1 in diabetic neuropathy and amyotrophic lateral sclerosis
2017, Neurobiology of DiseaseCitation Excerpt :When major regulators of apoptosis such as Caspase-3 (Kuida et al., 1996) or Apaf 1 (Cecconi et al., 1998) are depleted, massive overgrowth of the brain is observed, so that it even outgrows the skull. Cell death is also observed at early postnatal stages (Naruse and Keino, 1995). About 30% of neuronal cells seem to be eliminated during this period, in particular in layer II, III and IV of the early postnatal cortex.
Heterogeneity, Cell Biology and Tissue Mechanics of Pseudostratified Epithelia: Coordination of Cell Divisions and Growth in Tightly Packed Tissues
2016, International Review of Cell and Molecular BiologyCitation Excerpt :With respect to this, one might argue that both proliferation and minimization of cell extrusion/death lead to increased packing. However, cell death is not widespread in most PSE investigated to date (Dzafic et al., 2015; Milán et al., 1997; Naruse and Keino, 1995) and might often be negligible when it comes to its effect on total cell number and growth. Proliferation, on the other hand, is the major contributor to PSE cell numbers and we will thus continue our discussion with the assumption that cell extrusion/death can be neglected.
Postnatal neuronal apoptosis in the cerebral cortex: Physiological and pathophysiological mechanisms
2013, NeuroscienceCitation Excerpt :In order to find answers for these questions exhaustive analyses have been performed on the brains of mice, rats, cats, and hamsters, focusing on the first 30 days after birth. The results showed that approximately 32% of neuronal tissue is eliminated between postnatal day 5 (P5) and adult stages, with the consequence of relatively small loss of neurons during aging (reviewed in Naruse and Keino (1995)). In the mouse, examination of the period of time between P5 and P10 revealed a significant decrease of neuronal density in the mouse cortex (Heumann et al., 1978; Heumann and Leuba, 1983).
Tributyltin chloride results in dorsal curvature in embryo development of Sebastiscus marmoratus via apoptosis pathway
2011, ChemosphereCitation Excerpt :Acridine orange staining assay in the present study revealed that apoptosis mainly occurred in the twisted tail areas, which suggests that the developing tail may be an important potential target for TBT toxicity in S. marmoratus. Similarly, correlations between malformed organs and regions of apoptosis are observed in other embryos (reviewed in Naruse and Keino, 1995; Hammerman, 1998; Fisher et al., 2000). The study provided a possible mechanistic link between apoptosis and TBT-induced twisted tails abnormality.
Cytotoxic T-lymphocytes secrete soluble factors that induce caspase-mediated apoptosis in glioblastoma cell lines
2010, Journal of Neuroimmunology