Elsevier

Toxicology

Volume 91, Issue 1, 17 June 1994, Pages 15-27
Toxicology

Chapter 3 Organophosphorous compounds

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References (8)

  • International Commission on Occupational Health

    Biological Monitoring of Workers Manufacturing, Formulating and Applying Pesticides

  • R.B. Jaeger

    Cholinesterase inhibition as an indication of adverse toxicologic effect

  • M. Maroni

    Organophosphorous pesticides

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    Acute Cholinergic syndrome (ACS) occurs in acute poisonings with OP pesticides and involve wide range of both central and peripheral neurologic symptoms. These symptoms are directly related to levels of acetylcholinesterase (AChE) activity through the inhibition of cholinesterase, also called as cholinergic crisis, (Jeyaratnam and Maroni, 1994). Acute exposure to OP can be detected in plasma or erythrocytes for a brief period of time (minutes or hours) after exposure and normally subsides within days or weeks (Salvi et al., 2003).

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    These compounds owe their toxic effect to the inhibition of acetylcholinesterase (AChE) activity in the nervous tissue leading to the accumulation of acetylcholine at cholinergic synapses. The excess acetylcholine causes constant acetylcholine receptor triggering, resulting in malfunction of the autonomic and somatic nervous systems [6,7]. In addition to the inhibitory effect on AChE, the OP compounds can negatively affect different tissues by inducing histopathological and biochemical changes.

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