6-Alkyl-1,3,8-trichlorodibenzofurans as antiestrogens in female Sprague-Dawley rats
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Cited by (21)
Effects of the aryl hydrocarbon receptor agonist 3-methylcholanthrene on the 17β-estradiol regulated mRNA transcriptome of the rat uterus
2017, Journal of Steroid Biochemistry and Molecular BiologyCitation Excerpt :Nevertheless, initial evidence for the antiestrogenic effect of the AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) stems from uterotrophic assays, [11–13] showing that treatment with TCDD and other AHR ligands caused a decreased responsiveness of uterine wet weight to E2 and decreased hepatic and uterine ER and PR levels, leading to a diminished activity of the associated pathways. Furthermore antiestrogenic effects of TCDD in the uterus have been shown on a number of additional endpoints like peroxidase activity and EGFR binding activity [14,15]. This suggests that antiestrogenic effects of AHR ligands are of a global nature rather than being limited to the regulation of the expression of a small number of specific genes, but this has not been confirmed to date.
Alkyl polychlorinated dibenzofurans and related compounds as antiestrogens in the female rat uterus: Structure-activity studies
1995, Toxicology and Applied PharmacologyModulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds
1995, Pharmacology and TherapeuticsInhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists
1994, Molecular and Cellular EndocrinologyInteraction of 2,3,7,8-tetrachlorodibenzo-p-dioxin and retinoic acid in mcf-7 human breast cancer cells
1994, Toxicology and Applied Pharmacology