Elsevier

Toxicology

Volume 15, Issue 1, December 1979, Pages 55-64
Toxicology

Effects of dithiocarb the (+)-cyanidanol-3 on the hepatotoxicity and metabolism of vinylidene chloride in rats

https://doi.org/10.1016/0300-483X(79)90019-2Get rights and content

Abstract

The acute hepatotoxic effects of vinylidene chloride (VDC) were evidenced by measurement of the increase in the serum of the aminotransferase (GPT) and sorbitol dehydrogenase (SDH), hepatic glutathione (GSH) depletion and histological examinations in rats. The hepatoprotective agents dithiocarb and (+)-cyanidanol-3 proved well able to antagonize these toxic effects of VDC. While dithiocarb inhibited the in vivo metabolism of VDC in a closed exposure system, (+)-cyanidanol-3 had no influence at all. These findings substantiate the role of the microsomal monooxygenase system in the metabolism and hepatotoxicity of VDC. The mechanisms by which dithiocarb and (+)-cyanidanol-3 act as antihepatotoxic agents are different: the inhibition of the metabolic activation by dithiocarb and free radical-scavenging by (+)-cyanidanol-3.

References (29)

  • R.J. Jaeger et al.

    Exp. Mol. Pathol.

    (1974)
  • F.J. Lee et al.

    Lancet

    (1974)
  • G. Bonse et al.

    Biochem. Pharmacol.

    (1975)
  • M.J. McKenna et al.

    Toxicol. Appl. Pharmacol.

    (1978)
  • H. Greim et al.

    Biochem. Pharmacol.

    (1975)
  • M. Lang et al.

    Chem.-Biol. Interact

    (1976)
  • G. Ellman

    Arch. Biochem. Biophys.

    (1959)
  • C.-P. Siegers et al.

    Toxicol. Appl. Pharmacol.

    (1978)
  • A.E.M. McLean et al.

    Biochem. Pharmacol.

    (1978)
  • C. Maltoni et al.

    Ann. N.Y. Acad. Sci.

    (1975)
  • J.L. Creech et al.

    J. Occup. Med.

    (1974)
  • P.L. Viola et al.

    Environ. Health Perspect.

    (1977)
  • D. Reichert et al.

    Arch. Toxicol.

    (1979)
  • H. Bartsch et al.

    Nature

    (1975)
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