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Formulation effect on the dermal bioavailability of isothiazolone biocide

https://doi.org/10.1016/0278-6915(95)00114-XGet rights and content

Abstract

A central tenet of the science of toxicology is that the toxic effect of any material monotonically increases with the amount of the material delivered to the target tissue. This is the so-called dose-response relationship. Previous work is discussed in which a dose-response relationship is established for the induction and elicitation of cutaneous contact allergy from the isothiazolone biocide which is a 3 to 1 mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and 2-methyl-4-isothiazolin-3-one. The commercial product name for this mixture is Kathon® LX biocide. Given a tissue dose-response, this current work determines and demonstrates a difference in risk from aqueous formulations with and without polymer. A lower delivered dose of biocide goes into the skin from an aqueous-based polymeric emulsion or paint than from an aqueous solution or oil-in-water emulsions without polymer. Thus, the estimate of risk, as a direct result of dose, and the determination of a safe use level of a biocide in any particular formulation matrix need to incorporate this reality.

References (15)

  • P.K. Chan et al.

    Kathon biocide: manifestation of delayed contact dermatitis in guinea pigs is dependent on the concentration for induction and challenge

    Journal of Investigative Dermatology

    (1983)
  • O. Baadsgaard

    Immunologic mechanisms of contact dermatitis

  • C.A. Black et al.

    Kathon Biocide: In Vitro Dermal Absorption Study in Male Rat Skin (Data Summary)

  • R. Bonin et al.

    Delayed Contact Hypersensitivity Study in Guinea Pigs

  • A.A. Fisher

    Cosmetic dermatitis, part II. Reactions to some commonly used preservatives

    Cutis

    (1980)
  • M.A. Jayjock et al.

    Low-applied-dose extrapolation of induction and elicitation of contact allergy in the evaluation and management of sensitization risk from Kathon CG isothiazolone in products

    American Journal of Contact Dermatitis

    (1992)
  • B. Magnusson et al.

    Factors influencing allergic contact sensitization

There are more references available in the full text version of this article.

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