Effects of haloperidol and SCH 23390 on acoustic startle and prepulse inhibition under basal and stimulated conditions

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Abstract

Schwarzkopf, Steven B., John P. Bruno, and Tanmoy Mitra: Differential Effects of Haloperidol and SCH 23390 on Acoustic Startle and Prepulse Inhibition Under Basal and Stimulated Conditions. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1993, 17(6): 1023–1036.

  • 1.

    1. Adult Sprague-Dawley rats underwent startle testing for assessment of baseline startle amplitude and prepulse inhibition (PPI) of the startle reflex.

  • 2.

    2. Animals were tested after administration of either: saline, a selective D1 dopamine (DA) receptor antagonist, a relatively selective D2 DA antagonist, or combined low dose D1 and D2 antagonists.

  • 3.

    3. Changes due to antagonists were assessed with and without administration of the D1D2agonist apomorphine.

  • 4.

    4. Testing without apomorphine stimulation showed that both D1 and D2 antagonists reduce baseline startle and enhance PPI. Further, the two antagonists exhibited a synergistic interaction.

  • 5.

    5. Testing with apomorphine showed that D1 and D2 antagonists reduce apomorphineinduced startle enhancement. Again, the two exhibited a synergistic interaction.

  • 6.

    6. For PPI, the D2 but not D1 antagonist reduced the apomorphine effect. However, the D1 antagonist potentiated the effect of the D2 antagonist.

Keywords

acoustic startle reflex
baseline startle
dopamine
D1 receptor
D2 receptor
prepulse inhibition
synergism

Abbreviations

acoustic startle reflex (ASR)
dopamine (DA)
prepulse inhibition (PPI)

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