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Neurotransmitter changes in early- and late-onset alzheimer-type dementia

https://doi.org/10.1016/0278-5846(92)90106-OGet rights and content

Abstract

Arai Heii., Yosuke Ichimiya, Kenji Kosaka, Takashi Noroji and Reiji Iizuka: Neurotransmitter Changes in Early- and Late-onset Alzheimer-type Dementia. Prog. Neuro-Psychophamacol. & Biol. Psychiat. 1992, 16(6):883–890.

  • 1.

    1. Neurotransmitter-related markers were examined in Alzheimer-type dementia (ATD) and studied whether or not there is biochemical difference between the early- and late-onset sub-groups.

  • 2.

    2. Postmortem brains were obtained from neuropathologically diagnosed ATD patients and control subjects with no clinico-neuropathological findings indicative of neuropsychiatric diseases.

  • 3.

    3. Neurochemical data in the early- and late-onset groups were compared to the age-matched younger and older control groups, respectively, and expressed as a percentage of the mean value in the respective controls.

  • 4.

    4. Choline acetyltransferase activity and concentrations of serotonin and noradrenaline were more severely depleted in the early-onset ATD group than in the late-onset ATD group.

  • 5.

    5. These findings indicative of heterogeneity of ATD patients were discussed from the pathogenetic and therapeutic viewpoints.

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