Prostaglandins, Leukotrienes and Medicine
Prostacyclin synthesis by the corpora cavernosa of the human penis: Evidence for muscarinic control and pathological implications
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Cited by (48)
Pharmacology and perspectives in erectile dysfunction in man
2020, Pharmacology and TherapeuticsCitation Excerpt :Prostanoids are a heterogeneous group of substances with different physiological effects on the body. Penile erectile tissue is able to locally synthesize and metabolize most of these substances (Jeremy, Morgan, Mikhailidis, & Dandona, 1986; Khan et al., 1999; Minhas, Cartledge, & Eardley, 2000; Moreland et al., 2001). Production of thromboxane A2 (TXA2), prostaglandin F2α (PGF2α), prostacyclin (PGI2), prostaglandin D2 (PGD2), and prostaglandin E2 (PGE2) has been reported in HCC.
Effects of the essential oil of Croton zehntneri and its major components, anethole and estragole, on the rat corpora cavernosa
2014, Life SciencesCitation Excerpt :The release of relaxant prostanoids seems to have a predominant role in the relaxation of corpora cavernosa induced by both anethole and estragole. The main source of such compounds is the endothelium of the cavernous sinusoids and the smooth muscle of the corpora cavernosa (Kun et al., 2008; Angulo et al., 2002; Jeremy et al., 1986). A point that should be noted is that both compounds increased cAMP production, which is the main second messenger for relaxant prostanois such as PGE2 acting through EP2 receptors.
Impaired neurogenic and endothelium-dependent relaxant responses of corpus cavernosum smooth muscle from hyperthyroid rabbits
2001, European Journal of PharmacologyThe role of prostaglandins in penile erection
2000, Prostaglandins Leukotrienes and Essential Fatty Acids