ReviewFunction of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases
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2020, Pharmacology and TherapeuticsTailor-made purified human platelet lysate concentrated in neurotrophins for treatment of Parkinson's disease
2017, BiomaterialsCitation Excerpt :Given their physiological role in activating and modulating neuronal signaling pathways, neurotrophic growth factors represent a very promising, recently explored, disease-modifying biotherapy [2]. Recombinant (r-)platelet-derived growth factor (PDGF), brain-derived neurotrophic factor (BDNF), transforming growth factor (TGF)-β, basic-fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), administered via intracerebroventricular (ICV) or systemic routes, provide physiological functional benefits in several neurological pathologies, and enhance the survival of dopaminergic neurons in PD cellular and animal models [3,4]. However, recent randomized clinical studies using these single recombinant growth factors drugs did not improve conditions of patients with neurodegenerative conditions [5–7], suggesting that therapeutic approaches combining multiple, complementary neurotrophic growth factors should be evaluated to treat the physiologically complex pathological events associated with PD.
Prolonged controlled delivery of nerve growth factor using porous silicon nanostructures
2017, Journal of Controlled Release