Elsevier

Peptides

Volume 17, Issue 6, 1996, Pages 895-900
Peptides

Article
EM523L, a nonpeptide motilin agonist, stimulates gastric emptying and pancreatic polypeptide secretion

https://doi.org/10.1016/0196-9781(96)00143-XGet rights and content

Abstract

We investigated the efficacy and the mechanism of action of EM523L, a nonpeptide motilin agonist (motilide), on the stimulation of gastric emptying and on the release of gut peptides after ingestion of a solid meal in normal controls (n = 8) and in diabetic patients (n = 8) with signs of neuropathy. A dose of 2 mg EM523L was administered IV over 15 min just after ingestion of a solid meal (200 kcal). Gastric emptying was measured by a radionuclide technique. EM523L accelerated gastric emptying and markedly augmented postprandial pancreatic polypeptide (PP) response in both normal controls and diabetic patients. This may suggest the mediation of the vagal-cholinergic pathway to accelerate gastric emptying. The present study offers a promising therapeutic potential of the motilide in gastrointestinal motility disorders like those observed in diabetes mellitus.

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