Neuromedin U—A study of its distribution in the rat
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2019, Cell MetabolismCitation Excerpt :NMU did not affect GLP-1 secretion (baseline secretion, 233.8 ± 93.5 pmol/15 min versus NMU = 308.5 ± 123.9 pmol/15 min, p = 0.57, n = 5) although the positive control, taurine-deoxycholic acid, increased secretion 4-fold (from 405.6 ± 151 pmol/15 min to 1,391 ± 324 pmol/15 min; Figures S2A–S2C). NMU is a neuropeptide predominately expressed in the brain and small intestine (Augood et al., 1988; Domin et al., 1987). It was reported to attenuate glucose-stimulated insulin secretion from in situ perfused rat pancreas and perifused human islets (Alfa et al., 2015; Kaczmarek et al., 2006, 2009), which led to the proposal that NMU represents a new physiologically relevant inhibitory factor.
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