Elsevier

Neuroscience Research

Volume 5, Issue 2, December 1987, Pages 167-171
Neuroscience Research

Short communication
Depletion in substance P- and neurokinin A-like immunoreactivity in substantia nigra after ibotenate-induced lesions of striatum

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Abstract

Changes in substance P (SP)- and neurokinin A (NKA)-like immunoreactivity (LI) in the rat substantia nigra (SN) after striatal lesion produced by ibotenate were studied using immunohistochemical methods. Compared to the SN on the control side, both SP- and NKA-LI were dramatically depleted in the SN on the lesion side. These findings are consistent with the existence of SP- and/or NKA-containing neurons in the striatum projecting to the SN.

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