Potential behavioral modification of glucocorticoid damage to the hippocampus
References (69)
- et al.
Corticosterone impairs hippocampal neuronal calcium regulation: possible mediating mechanisms
Brain Res.
(1993) - et al.
Dexamethasone causes translocation of glucose transporters from the plasma membrane to an intracellular site in human fibroblasts
J. Biol. Chem.
(1987) Endocrinology alfresco: psychoendocrine studies of wild baboons
Rec. Prog. Hormone Res.
(1993)- et al.
Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
Biol. Psychiatry
(1992) - et al.
Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons
Brain Res.
(1992) - et al.
Exposure to excess glucocorticoids alters dendritic morphology of adult hippocampal pyramidal neurons
Brain Res.
(1990) - et al.
Glucocorticoid endangerment of hippocampal neurons is NMDA-receptor mediated
Brain Res.
(1990) - et al.
Biological differences between ischemia, hypoglycemia, and epilepsy
Ann. Neurol.
(1988) - et al.
Morphologische Veranderungen im Diencephalon und Telencephalon nach Störungen des regelkreises Adenohypophyse-Nebennierenrinde III. Ergebnisse beim Meerschweinchen nach Verabreichung von Cortison und Hydrocortison
Z. Zellforsch.
(1979) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
Ann. Neurol.
(1992)
Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
Neurobiol. Aging
Regulation of ACTH secretion: variations on a theme of B
Recent Prog. Horm. Res.
Enriching Heredity
Corticosterone enhances kainic acid-induced calcium mobilization in cultured hippocampal neurons
J. Neurochem.
Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo
J. Neurochem.
Prognostic value of the stress response following stroke
J. Am. Med. Assoc.
Expression of a glucose transporter gene cloned from brain in cellular models of insulin resistance: dexamethasone decreases transporter mRNA in primary cultured adipocytes
Mol. Endocrinol.
Steroids and neuronal destruction or stabilization
Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene
Glucocorticoids inhibit glucose transport in cultured hippocampal neurons and glia
Neuroendocrinology
Glucocorticoids aggravate the cholinergic deficit induced by ethylcholine aziridinium in rat hippocampus
Soc. Neurosci. Abstr.
Hypothalamic pituitary-adrenal activity in aged, cognitively unimpaired rats
J. Neurosci.
Glucocorticoids and 3,4-methylenedioxymethamphetamine (MDMA) induced neurotoxicity
Eur. J. Pharmacol.
Local cerebral glucose utilization is increased in acutely adrenalectomized rats
Neuroendocrinology
Corticosteroid modulation of hippocampal potentials: increased effect with aging
Science
Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging
J. Neurosci.
Chronic dexamethasone pretreatment aggravates ischemic neuronal necrosis
J. Cereb. Blood Flow Metab.
Rat hippocampal lactate efflux during electroconvulsive shock or stress is differentially dependent on entorhinal cortex and adrenal integrity
J. Neurochem.
Hippocampal aging and adrenocorticoids: a quantitative correlation
Science
Brain-aging correlates: retardation by hormonal-pharmacological treatments
Science
Plasma-free corticosteroid response to electric shock in rats stimulated in infancy
Science
The psychoneuroendocrinology of stress: a psychobiological perspective
Selective retention of corticosterone by limbic structures in rat brain
Nature
Cited by (94)
Variation in the Developing Brain and the Role of Pediatric Posttraumatic Stress on Structural and Functional Networks
2020, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingSevere stress and the development of the amygdala in youth: A theory and its statistical implications
2017, Developmental ReviewCitation Excerpt :The implicit theory that has largely driven simple comparison of stressed versus non-stressed samples (e.g., PTSD versus controls) is that stress may damage regions of the brain. For example, research suggests that glucocorticoids secreted during stress can damage areas of the brain such as the hippocampus (Sapolsky, 1993; Sapolsky, Uno, Rebert, & Finch, 1990). This damage includes alteration of pyramidal cell morphology, pyramidal cell death, and suppression of granule cells (Watanabe, Gould, & McEwen, 1992).
Combined effects of social stress and liver fluke infection in a mouse model
2016, Brain, Behavior, and ImmunityCitation Excerpt :Similar, but less pronounced, effects of social stress and liver fluke invasion were observed in cathepsin L activity. It is thought that the hippocampus is more vulnerable to damage, such as cerebral stroke and brain trauma, and is extremely sensitive to chronic stress (Sapolsky, 1993), which may lead to atrophy, as observed in a range of psychiatric disorders (McEwen, 2000), including MDD (Lee et al., 2002; Sheline et al., 1999). Acute stress and chronic stress decrease the brain-derived neurotrophic factor (BDNF) levels in the dentate gyrus and pyramidal neurons of the hippocampus as well as in the neocortex and amygdala but increase the BDNF level in the hypothalamus in rodents (Duman et al., 2001; Smith et al., 1995).
Similar cortical but not subcortical gray matter abnormalities in women with posttraumatic stress disorder with versus without dissociative identity disorder
2015, Psychiatry Research - NeuroimagingStress-induced metaplasticity: From synapses to behavior
2013, NeuroscienceDivergent hormonal responses to social competition in closely related species of haplochromine cichlid fish
2012, Hormones and Behavior