Research letter
Effects of vanillin on sister-chromatid exchanges and chromosome aberrations in human lymphocytes

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Cited by (25)

  • Kinetic and thermodynamic studies on the interaction between calf thymus DNA and food additive vanillin - electrochemical methods

    2022, Journal of Molecular Liquids
    Citation Excerpt :

    Synthetic vanillin is preferred in most applications due to its low cost. The compound has been found to have little cytotoxicity, mutagenicity, and clastogenicity on model biological tissues [2,3]. However, literature reports on the effect of vanillin on DNA are scarce and based on UV–vis absorption data [4].

  • Vanillin derivative VND3207 activates DNA-PKcs conferring protection against radiation-induced intestinal epithelial cells injury in vitro and in vivo

    2020, Toxicology and Applied Pharmacology
    Citation Excerpt :

    Thus, novel radioprotectors with minimal toxicity and high efficacy are urgently needed. Vanillin (4-hydroxy-3-methoxybenzaldehyde), a food-flavoring compound, has been reported to exhibit antioxidant and anti-mutagenic activities (Jansson and Zech, 1987; Kamat et al., 2000; Kumar et al., 2000; Sasaki et al., 1990). Our previous studies have reported that the vanillin derivative 4-hydroxy-3,5-dimethoxybenzaldehyde or VND3207 had more potent radio-protective and antioxidant effects than vanillin, protecting normal human lymphoblastoid AHH-1 cells and fibroblastoid HFS cells against γ-ray irradiation through promoting cell survival and DNA damage repair (Zheng et al., 2008).

  • The vanillin derivative VND3207 protects intestine against radiation injury by modulating p53/NOXA signaling pathway and restoring the balance of gut microbiota

    2019, Free Radical Biology and Medicine
    Citation Excerpt :

    Vanillin (4-hydroxy-3-methoxybenzaldehyde), the major component of vanilla, has been studied extensively in recent years for potential biomedical applications. Along with minimal cytotoxicity and genetic toxicity in cultured cells [4], vanillin exhibits potent antioxidant effects including inhibition of lipid peroxidation and hydroxyl radical scavenging [5–7]. In addition, it also exerts anti-mutagenic effects by inhibiting X-ray- and UV-induced single-strand DNA breaks, chromosomal breaks and DNA crosslinking [8], and promoting DNA ligation [9,10], repair and replication [11,12].

  • Antimutagens as cancer chemopreventive agents in the diet

    1994, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
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