Research letterEffects of vanillin on sister-chromatid exchanges and chromosome aberrations in human lymphocytes
References (9)
- et al.
Screening of tobacco smoke constituents for mutagenicity using the Ames test
Toxicology
(1980) - et al.
In vitro studies of biological effects of cigarette smoke condensate, II. Induction of sister chromatid exchanges in human lymphocytes by weakly acidic, semivolatile constituents
Mutation Res.
(1986) - et al.
Food flavourings and compounds of related structure, I. Acute oral toxicity
Food Cosmet. Toxicol.
(1964) - et al.
Genotoxicity of flavoring agents
Mutation Res.
(1982)
Cited by (25)
Kinetic and thermodynamic studies on the interaction between calf thymus DNA and food additive vanillin - electrochemical methods
2022, Journal of Molecular LiquidsCitation Excerpt :Synthetic vanillin is preferred in most applications due to its low cost. The compound has been found to have little cytotoxicity, mutagenicity, and clastogenicity on model biological tissues [2,3]. However, literature reports on the effect of vanillin on DNA are scarce and based on UV–vis absorption data [4].
Vanillin derivative VND3207 activates DNA-PKcs conferring protection against radiation-induced intestinal epithelial cells injury in vitro and in vivo
2020, Toxicology and Applied PharmacologyCitation Excerpt :Thus, novel radioprotectors with minimal toxicity and high efficacy are urgently needed. Vanillin (4-hydroxy-3-methoxybenzaldehyde), a food-flavoring compound, has been reported to exhibit antioxidant and anti-mutagenic activities (Jansson and Zech, 1987; Kamat et al., 2000; Kumar et al., 2000; Sasaki et al., 1990). Our previous studies have reported that the vanillin derivative 4-hydroxy-3,5-dimethoxybenzaldehyde or VND3207 had more potent radio-protective and antioxidant effects than vanillin, protecting normal human lymphoblastoid AHH-1 cells and fibroblastoid HFS cells against γ-ray irradiation through promoting cell survival and DNA damage repair (Zheng et al., 2008).
The vanillin derivative VND3207 protects intestine against radiation injury by modulating p53/NOXA signaling pathway and restoring the balance of gut microbiota
2019, Free Radical Biology and MedicineCitation Excerpt :Vanillin (4-hydroxy-3-methoxybenzaldehyde), the major component of vanilla, has been studied extensively in recent years for potential biomedical applications. Along with minimal cytotoxicity and genetic toxicity in cultured cells [4], vanillin exhibits potent antioxidant effects including inhibition of lipid peroxidation and hydroxyl radical scavenging [5–7]. In addition, it also exerts anti-mutagenic effects by inhibiting X-ray- and UV-induced single-strand DNA breaks, chromosomal breaks and DNA crosslinking [8], and promoting DNA ligation [9,10], repair and replication [11,12].
The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients
2005, Food and Chemical ToxicologyAntimutagens as cancer chemopreventive agents in the diet
1994, Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis