Trends in Pharmacological Sciences
ReviewsThe current endothelin receptor classification: time for reconsideration?
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Differences in endothelin receptor types in the vasculature of Bothrops jararaca (Viperidae) and Oxyrhopus guibei (Colubridae) snakes
2008, Comparative Biochemistry and Physiology - C Toxicology and PharmacologyCorrelation between vascular responsivensss and expression of novel transcripts of the ET<inf>A</inf>-receptor in human vascular tissue
2007, Vascular PharmacologyCitation Excerpt :Specific receptor subtypes for ET-1 encoded by separate genes are responsible for vasoconstriction (ETA and ETB receptors), vasodilatation via the release of vasoactive agents from the endothelium (ETB receptors) and mitogenesis (ETA receptors) (Galie et al., 2004). However, a number of observations relating to the effect of ETA receptor antagonists that do not fit with the current receptor classification remain unresolved (Bax and Saxena, 1994). These discrepancies are especially evident in studies with human blood vessels.
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2006, StructureCitation Excerpt :1H, 15N, and 13C chemical shifts were referenced relative to the frequency of the 2H lock resonance of water. Main-chain and side-chain assignments were obtained from a combination of standard triple resonance experiments (Bax and Saxena, 1994; Kay, 1997). 2D [1H, 15N]-HSQC and 3D [1H, 15N, 13C]-HNCO, HN(CA)CO, HNCA, HN(CO)CA, HNCACB, and CBCA(CO)NH spectra were used for the 1H, 15N, and 13C assignments of the main chain.
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