Trends in Pharmacological Sciences
Aldehyde dehydrogenase inhibitors as alcohol-sensitizing drugs: a pharmacological perspective
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Exploring the potential nutraceutical values of durian (Durio zibethinus L.) - An exotic tropical fruit
2015, Food ChemistryCitation Excerpt :Disulfiram can retard ALDH activity resulting in the accumulation of alcohol-derived acetaldehyde. According to some researchers (Brien & Loomis, 1985), acetaldehyde contributes to the adverse reactions known as the disulfiram-ethanol reaction (DER). The inhibitory activities of sulphur-containing compounds obtained from natural resources on ALDH are well known (Kitson & Weiner, 1996).
Biotransformation of durian pulp by mono- and mixed-cultures of Saccharomyces cerevisiae and Williopsis saturnus
2012, LWTCitation Excerpt :Maninang, Lizada, and Gemma (2009) found that the durian-alcohol anecdote could be attributed to the hydrophobic sulphides in durian that might cause the accumulation of acetaldehyde through the inhibition of aldehyde dehydrogenase by the hydrophobic sulphides. The acetaldehyde appears to play a central role in mediating the unpleasant physical responses characterized by nausea, vomiting, tachycardia and hypotension, which is similar to the disulfiram–ethanol reaction observed in clinical aversion therapy for recovering alcoholics (Brien & Loomis, 1985). In this study, the sulphides initially present in durian were transformed to trace levels (Fig. 3; Table 2), and thus, this may reduce the risk of consuming durian with ethanol and warrants further research.
The influence of durian (Durio zibethinus Murray cv. Monthong) on conditioned taste aversion to ethanol
2012, Food ChemistryCitation Excerpt :Disulfiram is known to inhibit aldehyde dehydrogenase (ALDH), causing the accumulation of ethanol-derived acetaldehyde (Hart & Faiman, 1992). Rather than ethanol itself, acetaldehyde appears to have a central role in mediating the adverse reactions referred to as the disulfiram-ethanol reaction or DER (Adinoff, Iranmanesh, Veldhuis, & Fisher, 1998; Brien & Loomis, 1985; Duranceaux et al., 2006; IARC, 1999; Tottmar & Hellstrom, 1979). The DER turns the penchant for alcohol drinking into aversive distaste.
Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agents
2007, International Congress SeriesCitation Excerpt :The severity of the DER varies widely between individuals, depending on how much acetaldehyde accumulates, which in turn is determined by how much alcohol is consumed, activity of AlDH and extent of its inhibition by disulfiram. Disulfiram, however, has both undesirable and sometimes unwelcome serious side effects [1–3], including drowsiness, severe hypotension, paresthesias (perverted sense of tingling, crawling, or burning of the skin, such as occurs in peripheral neuritis and spinal cord lesions), peripheral neuropathies, psychosis, and hepatitis, all of which reduce markedly the rate of compliance with self-administration of the drug and, hence, its efficacy. Calcium cyanamide, which is more widely used in Japan, also exerts other equally unwelcome toxic effects [4], e.g. persistent liver dysfunction, even with prolonged abstinence, and liver fibrosis and emergence of “ground glass” liver cells in those who relapse into drinking.
Overview of ALDH Polymorphism: Relation to Cardiovascular Effects of Alcohol
2005, Comprehensive Handbook of Alcohol Related Pathology