Issues of adrenoceptor behavior in respiratory and cutaneous disorders of atopic allergy

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Abstract

Emergence of the radioligand binding technology in the study of adrenoceptors has resulted in an array of new problems in current research on bronchial asthma and atopic dermatitis. These include (1) the similarities and differences between agonist-induced desensitization and manifestations of β-adrenergic subsensitivity in diseases of atopic allergy; (2) the nature of the reciprocal changes in α- and β-adrenergic reactivities as well as in their respective receptor concentrations; and (3) consideration of the various developmental mechanisms that may be operative in the induction of β-adrenergic subsensitivities in atopic disease.

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Cited by (0)

1

Dr Andor Szentivanyi came to the USA in 1957 from his native Hungary. He has held faculty positions at the Universities of Chicago, Colorado, Creighton and University of South Florida, where he currently serves as Vice-President for Medical Affairs and Dean of the College of Medicine.

2

Dr James Polson received his Ph.D. degree in pharmacology at the University of Missouri College of Medicine. Following two years of post-doctoral training in pharmacology at the University of Minnesota, he joined the College of Medicine faculty at the University of South Florida in 1971.

3

Dr Judith Szentivanyi received her MD degree from the University Medical School Debrecen, Hungary. She presently serves on the Clinical Faculty of the Department of Internal Medicine at the University of South Florida.

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