Cytokines in neuroinflammatory disease: role of myelin autoreactive T cell production of interferon-gamma
References (51)
- et al.
Peptides of myelin basic protein stimulate T lymphocytes from patients with multiple sclerosis
J. Neuroimmunol.
(1989) - et al.
Sulfosalzine treatment of experimental allergic encephalomyelitis in Lewis rats: disease relapse and increase of autoreactive T cells
J. Neuroimmunol.
(1991) - et al.
Reverse ELISPOT assay for clonal analysis of cytokine production. Enumeration of gamma-secreting cells
J. Immunol. Methods
(1988) - et al.
Interferon induces astrocyte maturation causing an increase in cholinergic properties of cultured human spinal cord cells
Developm. Biol.
(1989) - et al.
Immune activation in multiple sclerosis: study of IL-2, sIL-2R, and gamma-IFN levels in serum and cerebrospinal fluid
J. Neurol. Sci.
(1989) - et al.
Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein and myelin basic protein in multiple sclerosis
J. Neuroimmunol.
(1986) - et al.
Induction of Ia molecules on brain endothelium is related to susceptibility to experimental allergic encephalomyelitis
J. Neuroimmunol.
(1989) - et al.
Increased interleukin-1 production by peripheral blood mononuclear cells in patients with multiple sclerosis
J. Neurol. Sci.
(1991) - et al.
T cell immunity and interferon γ secretion during experimental allergic encephalomyelitis in Lewis rats
J. Neuroimmunol.
(1991) - et al.
Chronic effects of γ-interferon on quinolinic acid and indoleamine-2,3-dioxygenase in brain of C57BL6 mice
Brain Res.
(1991)
Direct injection of cytokines into the spinal cord causes autoimmune encephalomyelitis-like inflammation
J. Neurol. Sci.
Rat ependyma and microglia cells express class II MHC antigens after intravenous infusion of recombinant gamma interferon
J. Neuroimmunol.
Assessment of the inhibitory effect of immunosuppressive agents on rat T cell interferon-γ production using an ELISPOT assay
J. Immunol. Methods
Molecular transductional mechanisms by which IFN-γ and other signals regulate macrophage development
Immunol. Rev.
Depletion of CD8+ T cells suppresses growth of Trypanosoma brucei brucei and IFN-γ production in infected rats
Clin. Exp. Immunol.
Regulation of human IgE synthesis. I. Human IgE synthesis in vitro is determined by the reciprocal antagonistic effects of interleukin 4 and interferon-γ
Eur. J. Immunol.
Differential tumor necrosis factor α expression by astrocytes from experimental allergic encephalomyelitis — susceptible and resistant rat strains
J. Exp. Med.
Gamma-interferon enhances macrophage transcription of the tumor necrosis factor/cachectin, interleukin-1, and uronkinase genes, which are controlled by short-lived repressors
J. Exp. Med.
Interferon-gamma regulates an antigen specific for endothelial cells involved in lymphocyte traffic
Astrocytes as antigen-presenting cells. I. Induction of Ia antigen expression on astrocytes by T cells via immune-interferon, and its effect on antigen presentations
J. Immunol.
Interleukin-6 is elevated in plasma in multiple sclerosis
J. Neuroimmunol.
Regulation of macrophage function by interferon-γ. Somatic cell genetic approaches in murine macrophage cell lines to mechanisms of growth inhibition, the oxidative burst, and expression of the chronic granulomatous disease gene
J. Clin. Invest.
Anti-interferon treatment blocks the ability of glutaraldehyde-polymerized allergens to inhibit specific IgE responses
J. Exp. Med.
The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones
J. Immunol.
Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cells
J. Exp. Med.
Cited by (131)
The novel small molecule TPN10518 alleviates EAE pathogenesis by inhibiting AP1 to depress Th1/Th17 cell differentiation
2023, International ImmunopharmacologyProlonged STAT1 activation in neurons drives a pathological transcriptional response
2023, Journal of NeuroimmunologyInduction of antigen-specific tolerance by hepatic AAV immunotherapy regardless of T cell epitope usage or mouse strain background
2023, Molecular Therapy Methods and Clinical DevelopmentImmune-related adverse events of checkpoint inhibitors: Insights into immunological dysregulation
2020, Clinical ImmunologyDysfunction of CD3<sup>−</sup>CD16<sup>+</sup>CD56<sup>dim</sup> and CD3<sup>−</sup>CD16<sup>−</sup>CD56<sup>bright</sup> NK cell subsets in RR-MS patients
2018, Clinical ImmunologyCitation Excerpt :Also, investigation of NKR expression profiles in association with disease duration might provide another perspective in MS pathogenesis. IFN-γ plays important roles in autoimmune diseases and for years, IFN-γ producing Th1 cells have been claimed as plausible pathogenic factors for MS development [36,37]. CD3−CD16+CD56dim NK cells are known to be the early producers of IFN-γ upon stimulation and their IFN-γ levels were reported to be decreased after 16 h [38], whereas CD3−CD16−CD56bright NK cells secrete large amounts of IFN-γ even after days.
The tolerogenic role of IFN-γ
2018, Cytokine and Growth Factor ReviewsCitation Excerpt :This coincides with our current understanding of EAE pathology (as well as that of multiple sclerosis (MS)), which involves several immune cell types of both innate and adaptive immunity, although pathogenic Th1 and Th17 clones seem to play the most fundamental roles. Initially, it was accepted that pathogenic Th1 cell clones are the main cause of disease initiation and progression [40,41]. We now know that Th17 effector cells also play a pivotal role in EAE and MS, as well as in various other ADs [42,43].