Lack of mutagenicity of diphenylhydantoin in in vitro short-term tests
References (38)
Cytogenetic testing of antiepileptic drugs in human patients
Mutation Res.
(1975)- et al.
Teratogenicity and lethality of hydantoin derivatives in the mouse: Structure—toxicity relationships
Toxicol. Appl. Pharmacol.
(1982) An improved nutrient solution for diploid Chinese hamster and human cell lines
Exp. Cell Res.
(1963)- et al.
The fetal hydantoin syndrome
J. Pediat.
(1975) - et al.
Risks to the offspring of women treated with hydantoin anticonvulsants, with emphasis on the fetal hydantoin syndrome
J. Pediat.
(1976) - et al.
Diphenylhydantoin teratogenicity in rats
Toxicol. Appl. Pharmacol.
(1972) - et al.
A new Salmonella tester strain for the detection of frameshift mutagens: A run of cytosines as a mutational hot spot
Mutation Res.
(1982) - et al.
Effects of 5,5-diphenylhydantoin and related carbamates and hydroxylamines on nucleic acid and protein synthesis of proliferating human lymphocytes
Toxicol. Appl. Pharmacol.
(1975) Anticonvulsant drugs and congenital abnormalities
Lancet
(1968)- et al.
Mutagenicity of diphenylhydantoin and some of its metabolites towards Salmonella typhimurium strains
Mutation Res.
(1982)
Teratogenic effect of anticonvulsants
Lancet
(1972)
Maternal epilepsy and abnormalities of the fetus and newborn
Lancet
(1972)
Diphenylhydantoin: Effect on the chromosomes of human leukocytes
Am. J. Obstet. Gynecol.
(1971)
An improved bacterial test system for the detection and classification of mutagens and carcinogens
Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test
Mutation Res.
(1975)
Phenytoin: An evaluation of several potential teratogenic mechanisms
Epilepsia
(1977)
Phenytoin-induced cardiac malformation in A/J mice
Teratology
(1980)
Phenytoin-induced teratogenesis: A mouse model
Science
(1981)
Teratogenic effects of diphenylhydantoin in Swiss-Webster and A/J mice
Cited by (14)
Phenytoin – An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology
2020, Food and Chemical ToxicologyCitation Excerpt :Data on mutagenicity, carcinogenicity, and teratogenicity are provided in separate subchapters. The mutagenicity of phenytoin and the mutagenicity of its major metabolite, 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH), have been tested in vitro on different Salmonella typhimurium strains (TA1535, TA100, TA1537, TA1538, TA98) using an Ames test (Sezzano et al., 1982; Léonard et al., 1984; Riedel and Obe, 1984). From the results of these studies, it was concluded that phenytoin does not have mutagenic properties.
Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens: I. Sensitivity, specificity and relative predictivity
2005, Mutation Research - Genetic Toxicology and Environmental MutagenesisThe genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity
2004, Mutation Research - Reviews in Mutation ResearchEffect of anticonvulsants on human chromosomes. 2. In vitro studies
1988, Mutation Research/Genetic ToxicologyOxidative stress-induced homologous recombination as a novel mechanism for phenytoin-initiated toxicity
2003, Journal of Pharmacology and Experimental Therapeutics
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